| Reaction Details |
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 | Report a problem with these data |
| Target | Adenosine receptor A2a |
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| Ligand | BDBM303280 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | A2a Ki assay |
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| Ki | 0.300±n/a nM |
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| Citation |  Ali, A; Kuang, R; Lim, Y; Lo, MM; Ting, PC; Biju, P; de Lera Ruiz, M; Degrado, SJ; Tung, AL; Henderson, TJ; Hong, L; Kim, J; Kim, DW; Lee, J; Wu, J; Wu, H; Xiao, Y; Yu, T; Zhou, G; Zhu, X; McCormick, KD; Tagat, JR; Xiao, D; Khan, T; Cao, J; Berlin, M; Zhang, Y Aminoquinazoline compounds as A2A antagonist US Patent US10138212 Publication Date 11/27/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Adenosine receptor A2a |
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| Name: | Adenosine receptor A2a |
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| Synonyms: | A2A adenosine receptor (hA2A) | AA2AR_HUMAN | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR) |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 44716.46 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P29274 |
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| Residue: | 412 |
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| Sequence: | MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAI
PFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTR
AKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYF
NFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVG
LFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFR
KIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNG
YALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
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| BDBM303280 |
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| n/a |
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| Name | BDBM303280 |
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| Synonyms: | 2-amino-N-[[6-[(4- fluorophenoxy)methyl]- 2-pyridyl]methyl]-8- methoxy-quinazoline-4- carboxamide | US10138212, Example 45 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H20FN5O3 |
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| Mol. Mass. | 433.435 |
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| SMILES | COc1cccc2c(nc(N)nc12)C(=O)NCc1cccc(COc2ccc(F)cc2)n1 |$;;;;;;;;;;;;;;;HN;;;;;;;;;;;;;;;;$| |
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| Structure | 
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