| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Adenosine receptor A2a |
|---|
| Ligand | BDBM303344 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | A2a Ki assay |
|---|
| Ki | 1.90±n/a nM |
|---|
| Citation |  Ali, A; Kuang, R; Lim, Y; Lo, MM; Ting, PC; Biju, P; de Lera Ruiz, M; Degrado, SJ; Tung, AL; Henderson, TJ; Hong, L; Kim, J; Kim, DW; Lee, J; Wu, J; Wu, H; Xiao, Y; Yu, T; Zhou, G; Zhu, X; McCormick, KD; Tagat, JR; Xiao, D; Khan, T; Cao, J; Berlin, M; Zhang, Y Aminoquinazoline compounds as A2A antagonist US Patent US10138212 Publication Date 11/27/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Adenosine receptor A2a |
|---|
| Name: | Adenosine receptor A2a |
|---|
| Synonyms: | A2A adenosine receptor (hA2A) | AA2AR_HUMAN | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR) |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 44716.46 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P29274 |
|---|
| Residue: | 412 |
|---|
| Sequence: | MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAI
PFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTR
AKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYF
NFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVG
LFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFR
KIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNG
YALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
|
|
|
|---|
| BDBM303344 |
|---|
| n/a |
|---|
| Name | BDBM303344 |
|---|
| Synonyms: | 2-amino-N-[dideuterio- [6-[dideuterio-[3-(2- methoxyethoxy)phenyl] methyl]-2- pyridyl]methyl]-8- methoxy-quinazoline- 4-carboxamide | US10138212, Example 106 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H27N5O4 |
|---|
| Mol. Mass. | 477.5483 |
|---|
| SMILES | [2H]C([2H])(NC(=O)c1nc(N)nc2c(OC)cccc12)c1cccc(n1)C([2H])([2H])c1cccc(OCCOC)c1 |$;;;HN;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;$| |
|---|
| Structure | 
|
|---|
Search and Browse
