Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetReceptor-interacting serine/threonine-protein kinase 2
LigandBDBM303364
Substrate/Competitorn/a
Meas. Tech.V9103X ADP-Glo Kinase Assay Custom
IC50 1.40±n/a nM
Citation Cui, JGao, DALiu, PMcKibben, BPMiller, CARazavi, HSpencer, ERuppel, SPadyana, AK Substituted benzamides as RIPK2 inhibitors US Patent US10138222 Publication Date 11/27/2018
More Info.:Get all data from this article,  Assay Method
 
Receptor-interacting serine/threonine-protein kinase 2
Name:Receptor-interacting serine/threonine-protein kinase 2
Synonyms:CARDIAK | RICK | RIP2 | RIPK2 | RIPK2_HUMAN | Serine/threonine-protein kinase RIPK2 | Tyrosine-protein kinase RIPK2 | receptor-interacting serine/threonine-protein kinase 2
Type:Protein
Mol. Mass.:61201.30
Organism:Homo sapiens (Human)
Description:n/a
Residue:540
Sequence:
MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSER
KDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPL
RFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRS
SKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMY
SVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEI
TFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPET
SRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIIN
PLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTK
PTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM303364
n/a
NameBDBM303364
Synonyms:BDBM303369 | US10138222, Example 79
TypeSmall organic molecule
Emp. Form.C27H32N6O2
Mol. Mass.472.582
SMILESCc1ccc(cc1-c1cnn(c1)-c1cncc(NC2CCN(CC2)C2COC2)c1)C(=O)NC1CC1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: