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TargetTyrosine-protein kinase BTK
LigandBDBM303641
Substrate/Competitorn/a
Meas. Tech.BTK Assay
IC50 2.30±n/a nM
Citation Bentzien JBerry AKBosanac TBurke MJDisalvo DTHoran JCLiang SMao CMao WShen YSoleymanzadeh FZindell RM Heteroaromatic compounds as BTK inhibitors US Patent  US10138229 Publication Date 11/27/2018
More Info.:Get all data from this article,  Assay Method
 
Tyrosine-protein kinase BTK
Name:Tyrosine-protein kinase BTK
Synonyms:ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK)
Type:Enzyme
Mol. Mass.:76289.95
Organism:Homo sapiens (Human)
Description:Q06187
Residue:659
Sequence:
MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEK
ITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEEL
RKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSS
HRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDE
YFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGK
EGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELIN
YHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGK
WRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANG
CLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDF
GLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYER
FTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM303641
n/a
NameBDBM303641
Synonyms:US10138229, Example 153
TypeSmall organic molecule
Emp. Form.C21H25N5O3
Mol. Mass.395.4549
SMILESCOc1ccc(cc1)-c1nn([C@H]2C[C@]3(C2)CCN(C3)C(=O)C=C)c(N)c1C(N)=O |r,wU:11.11,13.16,wD:13.20,(1.49,8.19,;-0,7.79,;-.4,6.31,;.69,5.22,;.29,3.73,;-1.2,3.33,;-2.29,4.42,;-1.89,5.91,;-1.6,1.84,;-.69,.6,;-1.6,-.65,;-.83,-1.98,;.66,-2.38,;.26,-3.87,;-1.22,-3.47,;-.64,-5.11,;.26,-6.36,;1.73,-5.88,;1.73,-4.34,;3.06,-6.65,;3.06,-8.19,;4.39,-5.88,;5.73,-6.65,;-3.06,-.17,;-4.39,-.94,;-3.06,1.37,;-4.39,2.14,;-4.39,3.68,;-5.73,1.37,)|
Structure
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