| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Receptor-interacting serine/threonine-protein kinase 2 |
|---|
| Ligand | BDBM303912 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | V9103X ADP-Glo Kinase Assay |
|---|
| IC50 | 1.60±n/a nM |
|---|
| Citation |  Liu, P; Miller, CA; Yu, M; Zhang, Z; Ruppel, S; Padyana, AK Substituted benzamides as RIPK2 inhibitors US Patent US10138241 Publication Date 11/27/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Receptor-interacting serine/threonine-protein kinase 2 |
|---|
| Name: | Receptor-interacting serine/threonine-protein kinase 2 |
|---|
| Synonyms: | CARDIAK | RICK | RIP2 | RIPK2 | RIPK2_HUMAN | Serine/threonine-protein kinase RIPK2 | Tyrosine-protein kinase RIPK2 | receptor-interacting serine/threonine-protein kinase 2 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 61201.30 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 540 |
|---|
| Sequence: | MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSER
KDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPL
RFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRS
SKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMY
SVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEI
TFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPET
SRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIIN
PLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTK
PTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM
|
|
|
|---|
| BDBM303912 |
|---|
| n/a |
|---|
| Name | BDBM303912 |
|---|
| Synonyms: | US10138241, Example 99 | US11130754, Example 99 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H27FN6O |
|---|
| Mol. Mass. | 458.5306 |
|---|
| SMILES | CN1CC[C@H](C1)c1ccc2ncc(-n3cc(cn3)-c3cc(C(=O)NC4CC4)c(F)cc3C)n2c1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
