| Reaction Details |
|---|
 | Report a problem with these data |
| Target | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A |
|---|
| Ligand | BDBM304037 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Assay of Phosphodiesterase 10 Inhibition In Vitro |
|---|
| IC50 | 84.0±n/a nM |
|---|
| Citation |  Moszczynski-Petkowski, R; Bojarski, L; Wieczorek, M; Majer, J; Janowska, S; Matloka, M; Borkowska, M; Stefaniak, F; Lamparska-Przybysz, M; Dubiel, K Fused triazole derivatives as phosphodiesterase 10A inhibitors US Patent US10138245 Publication Date 11/27/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A |
|---|
| Name: | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A |
|---|
| Synonyms: | 3',5'-cyclic phosphodiesterase | PDE10A | PDE10_HUMAN | Phosphodiesterase 10 (PDE10) | Phosphodiesterase 10A |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 88412.52 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9Y233 |
|---|
| Residue: | 779 |
|---|
| Sequence: | MRIEERKSQHLTGLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRKNNKSEDESAP
KEVSRYQDTNMQGVVYELNSYIEQRLDTGGDNQLLLYELSSIIKIATKADGFALYFLGEC
NNSLCIFTPPGIKEGKPRLIPAGPITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLE
SGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVC
RGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELY
SDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYT
GYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYHR
IRHSECIYRVTMEKLSYHSICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIF
VYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTD
LERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNI
FSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMM
TACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFY
NAVAIPCYTTLTQILPPTEPLLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASED
|
|
|
|---|
| BDBM304037 |
|---|
| n/a |
|---|
| Name | BDBM304037 |
|---|
| Synonyms: | 5,8-Dimethyl-2-[2-(1,3-thiazol-2-yl)-1H-benz-imidazol-5-yl][1,2,4]triazolo[1,5-a]pyrazine | US10138245, Example 8 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H13N7S |
|---|
| Mol. Mass. | 347.397 |
|---|
| SMILES | Cc1cnc(C)c2nc(nn12)-c1ccc2[nH]c(nc2c1)-c1nccs1 |
|---|
| Structure | 
|
|---|
Search and Browse
