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TargetOxysterols receptor LXR-beta
LigandBDBM50177011
Substrate/Competitorn/a
Meas. Tech.LXR alpha/beta Radioligand Binding Assay
Ki 4.00±n/a nM
Citation Claremon DADong CFan YLeftheris KLotesta SDSingh SBTice CMZhao WZheng YZhuang L Piperazine derivatives as liver X receptor modulators US Patent  US10144715 Publication Date 12/4/2018  Article
More Info.:Get all data from this article,  Assay Method
 
Oxysterols receptor LXR-beta
Name:Liver X receptor (LXR alpha AND LXR beta)
Synonyms:Liver X receptor beta (NR1H2) | Liver X, LXR beta | Oxysterols receptor LXR-beta
Type:Protein
Mol. Mass.:50978.79
Organism:Homo sapiens (Human)
Description:P55055
Residue:460
Sequence:
MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDW
VIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGA
RRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQ
SQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKR
SFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQI
ALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMR
RLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRM
LMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
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  Blast E-value cutoff:
BDBM50177011
n/a
NameBDBM50177011
Synonyms:CHEMBL3815014 | US10144715, Compound 7-13
TypeSmall organic molecule
Emp. Form.C19H23F3N4O2S
Mol. Mass.428.472
SMILESCC(C)[C@@H]1CN(CCN1c1nccc(n1)C(F)(F)F)c1cccc(c1)S(C)(=O)=O |r|
Structure
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