Reaction Details | |||
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Target | Oxysterols receptor LXR-beta | ||
Ligand | BDBM304616 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | LXR alpha/beta Radioligand Binding Assay | ||
Ki | 2.00±n/a nM | ||
Citation | Claremon, DA; Dong, C; Fan, Y; Leftheris, K; Lotesta, SD; Singh, SB; Tice, CM; Zhao, W; Zheng, Y; Zhuang, L Piperazine derivatives as liver X receptor modulators US Patent US10144715 Publication Date 12/4/2018 | ||
More Info.: | Get all data from this article, Assay Method | ||
Oxysterols receptor LXR-beta | |||
Name: | Oxysterols receptor LXR-beta | ||
Synonyms: | LXRB | Liver X receptor beta (NR1H2) | Liver X, LXR beta | NER | NR1H2 | NR1H2_HUMAN | Nuclear receptor NER | UNR | Ubiquitously-expressed nuclear receptor | ||
Type: | Enzyme Catalytic Domain | ||
Mol. Mass.: | 50978.79 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P55055 | ||
Residue: | 460 | ||
Sequence: |
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BDBM304616 | |||
n/a | |||
Name | BDBM304616 | ||
Synonyms: | (S)-2-isopropyl-4-(3-(methylsulfonyl)phenyl)-1-(((1s,4R)-4-(trifluoromethyl)cyclohexyl)methyl)piperazine | US10144715, Compound 48-11 | ||
Type | Small organic molecule | ||
Emp. Form. | C22H34N2O4S | ||
Mol. Mass. | 422.581 | ||
SMILES | CC(C)[C@H]1CN(CCN1C(=O)C1CC[C@@](C)(O)CC1)c1cccc(c1)S(C)(=O)=O |r,wU:14.16,wD:3.2,14.15,(-5.5,4.22,;-3.96,4.22,;-3.19,2.89,;-3.19,5.56,;-1.65,5.56,;-.88,6.89,;-1.65,8.22,;-3.19,8.22,;-3.96,6.89,;-5.5,6.89,;-6.27,5.56,;-6.27,8.22,;-7.81,8.22,;-8.58,9.56,;-7.81,10.89,;-8.58,12.22,;-7.04,12.22,;-6.27,10.89,;-5.5,9.56,;.66,6.89,;1.43,5.56,;2.97,5.56,;3.74,6.89,;2.97,8.22,;1.43,8.22,;3.74,9.56,;2.97,10.89,;5.07,10.33,;5.07,8.79,)| | ||
Structure |