Reaction Details | |||
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Target | Oxysterols receptor LXR-beta | ||
Ligand | BDBM304682 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | LXR alpha/beta Radioligand Binding Assay | ||
Ki | 3.00±n/a nM | ||
Citation | Claremon, DA; Dong, C; Fan, Y; Leftheris, K; Lotesta, SD; Singh, SB; Tice, CM; Zhao, W; Zheng, Y; Zhuang, L Piperazine derivatives as liver X receptor modulators US Patent US10144715 Publication Date 12/4/2018 | ||
More Info.: | Get all data from this article, Assay Method | ||
Oxysterols receptor LXR-beta | |||
Name: | Oxysterols receptor LXR-beta | ||
Synonyms: | LXRB | Liver X receptor beta (NR1H2) | Liver X, LXR beta | NER | NR1H2 | NR1H2_HUMAN | Nuclear receptor NER | UNR | Ubiquitously-expressed nuclear receptor | ||
Type: | Enzyme Catalytic Domain | ||
Mol. Mass.: | 50978.79 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P55055 | ||
Residue: | 460 | ||
Sequence: |
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BDBM304682 | |||
n/a | |||
Name | BDBM304682 | ||
Synonyms: | (4-((S)-3-isopropyl-4-(((1s,4R)-4-methoxy-4-(trifluoromethyl)cyclohexyl)methyl)piperazin-1-yl)-2-(methylsulfonyl)phenyl)methanol | US10144715, Compound 48-80 | ||
Type | Small organic molecule | ||
Emp. Form. | C24H37F3N2O4S | ||
Mol. Mass. | 506.622 | ||
SMILES | CO[C@@]1(CC[C@H](CN2CCN(C[C@@H]2C(C)C)c2ccc(CO)c(c2)S(C)(=O)=O)CC1)C(F)(F)F |r,wU:2.32,wD:5.5,12.13,2.1,(-4.86,4.25,;-5.95,3.16,;-5.55,1.67,;-4.06,2.07,;-2.98,.98,;-3.37,-.51,;-2.28,-1.59,;-.8,-1.2,;-.4,.29,;1.09,.69,;2.18,-.4,;1.78,-1.89,;.29,-2.28,;-.11,-3.77,;-1.59,-4.17,;.98,-4.86,;3.67,,;4.75,-1.09,;6.24,-.69,;6.64,.8,;8.13,1.2,;8.53,2.68,;5.55,1.89,;4.06,1.49,;5.95,3.37,;7.44,2.98,;6.35,4.86,;4.46,3.77,;-4.86,-.9,;-5.95,.18,;-7.04,2.07,;-8.53,2.47,;-6.64,3.56,;-7.44,.58,)| | ||
Structure |