| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-hexosaminidase subunit beta |
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| Ligand | BDBM304327 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition of Mast Cell Degranulation |
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| IC50 | 3800±n/a nM |
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| Citation |  Schlechtingen, G; Knolker, H; Friedrichson, T; Jennings, G; Braxmeier, T Hydroxy-substituted amino and ammonium derivatives and their medical use US Patent US10143668 Publication Date 12/4/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-hexosaminidase subunit beta |
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| Name: | Beta-hexosaminidase subunit beta |
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| Synonyms: | Beta-N-acetylhexosaminidase subunit beta | Beta-hexosaminidase subunit beta | Beta-hexosaminidase subunit beta (Hex B) | HEXB | HEXB_HUMAN | Hexosaminidase subunit B |
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| Type: | Enzyme |
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| Mol. Mass.: | 63112.58 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P07686 |
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| Residue: | 556 |
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| Sequence: | MELCGLGLPRPPMLLALLLATLLAAMLALLTQVALVVQVAEAARAPSVSAKPGPALWPLP
LSVKMTPNLLHLAPENFYISHSPNSTAGPSCTLLEEAFRRYHGYIFGFYKWHHEPAEFQA
KTQVQQLLVSITLQSECDAFPNISSDESYTLLVKEPVAVLKANRVWGALRGLETFSQLVY
QDSYGTFTINESTIIDSPRFSHRGILIDTSRHYLPVKIILKTLDAMAFNKFNVLHWHIVD
DQSFPYQSITFPELSNKGSYSLSHVYTPNDVRMVIEYARLRGIRVLPEFDTPGHTLSWGK
GQKDLLTPCYSRQNKLDSFGPINPTLNTTYSFLTTFFKEISEVFPDQFIHLGGDEVEFKC
WESNPKIQDFMRQKGFGTDFKKLESFYIQKVLDIIATINKGSIVWQEVFDDKAKLAPGTI
VEVWKDSAYPEELSRVTASGFPVILSAPWYLDLISYGQDWRKYYKVEPLDFGGTQKQKQL
FIGGEACLWGEYVDATNLTPRLWPRASAVGERLWSSKDVRDMDDAYDRLTRHRCRMVERG
IAAQPLYAGYCNHENM
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| BDBM304327 |
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| n/a |
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| Name | BDBM304327 |
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| Synonyms: | US10143668, Compound 1a |
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| Type | Small organic molecule |
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| Emp. Form. | C25H53N2O6 |
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| Mol. Mass. | 477.6976 |
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| SMILES | CCCCCCCCCCCCCC[N+](C)(C)CC(=O)N(C)C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO |r| |
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| Structure | 
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