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TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H]
LigandBDBM247707
Substrate/Competitorn/a
Meas. Tech.Fluorescence Biochemical Assay
pH7.5±n/a
Temperature298.15±n/a K
IC50 3.00±n/a nM
Commentsextracted
Citation Caferro, TRChen, ZCho, YSCostales, AQLevell, JRLiu, GManning, JRSendzik, MShafer, CShultz, MDSutton, JCWang, YZhao, Q 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH US Patent US9688672 Publication Date 6/27/2017
More Info.:Get all data from this article,  Assay Method
 
Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]
Name:Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]
Synonyms:Cytosolic NADP-isocitrate dehydrogenase (IDH1)(R132H) | IDH1 | IDH1 R132H | IDH1(R132H) | IDHC_HUMAN | Isocitrate dehydrogenase (IDH1)(R132H) | Isocitrate dehydrogenase 1 mutant (R132H) | Isocitrate dehydrogenase [NADP] cytoplasmic (IDH)(R132H) | Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1)(R132H) | Isocitrate dehydrogenase [NADP] cytoplasmic (R132H) | PICD
Type:Protein
Mol. Mass.:46641.74
Organism:Homo sapiens (Human)
Description:Human IDH1 R132H (SEQ ID No. 2 in patent). First three are removed. Google patent parsed wrong.
Residue:414
Sequence:
MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA
AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL
VSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM
GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE
AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG
KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE
EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM247707
n/a
NameBDBM247707
Synonyms:US10112931, Example 309 | US9434719, 309 | US9688672, Example 309
TypeSmall organic molecule
Emp. Form.C20H20Cl2N6O3
Mol. Mass.463.317
SMILESC[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2cn(cn2)-c2ccc(Cl)cc2)n1 |r|
Structure
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