Reaction Details |
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Target | Lethal factor |
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Ligand | BDBM8503 |
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Substrate/Competitor | Peptide Substrate |
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Meas. Tech. | Fluorescence Resonance Energy Transfer Assay (FRET) |
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IC50 | 54±n/a nM |
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Citation | Xiong, Y; Wiltsie, J; Woods, A; Guo, J; Pivnichny, JV; Tang, W; Bansal, A; Cummings, RT; Cunningham, BR; Friedlander, AM; Douglas, CM; Salowe, SP; Zaller, DM; Scolnick, EM; Schmatz, DM; Bartizal, K; Hermes, JD; MacCoss, M; Chapman, KT The discovery of a potent and selective lethal factor inhibitor for adjunct therapy of anthrax infection. Bioorg Med Chem Lett16:964-8 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Lethal factor |
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Name: | Lethal factor |
Synonyms: | Anthrax Lethal Factor (LF) | Anthrax lethal factor | Antrax lethal toxin | LEF_BACAN | lef | lethal factor |
Type: | PROTEIN |
Mol. Mass.: | 93758.56 |
Organism: | Bacillus anthracis |
Description: | ChEMBL_1460338 |
Residue: | 809 |
Sequence: | MNIKKEFIKVISMSCLVTAITLSGPVFIPLVQGAGGHGDVGMHVKEKEKNKDENKRKDEE
RNKTQEEHLKEIMKHIVKIEVKGEEAVKKEAAEKLLEKVPSDVLEMYKAIGGKIYIVDGD
ITKHISLEALSEDKKKIKDIYGKDALLHEHYVYAKEGYEPVLVIQSSEDYVENTEKALNV
YYEIGKILSRDILSKINQPYQKFLDVLNTIKNASDSDGQDLLFTNQLKEHPTDFSVEFLE
QNSNEVQEVFAKAFAYYIEPQHRDVLQLYAPEAFNYMDKFNEQEINLSLEELKDQRMLAR
YEKWEKIKQHYQHWSDSLSEEGRGLLKKLQIPIEPKKDDIIHSLSQEEKELLKRIQIDSS
DFLSTEEKEFLKKLQIDIRDSLSEEEKELLNRIQVDSSNPLSEKEKEFLKKLKLDIQPYD
INQRLQDTGGLIDSPSINLDVRKQYKRDIQNIDALLHQSIGSTLYNKIYLYENMNINNLT
ATLGADLVDSTDNTKINRGIFNEFKKNFKYSISSNYMIVDINERPALDNERLKWRIQLSP
DTRAGYLENGKLILQRNIGLEIKDVQIIKQSEKEYIRIDAKVVPKSKIDTKIQEAQLNIN
QEWNKALGLPKYTKLITFNVHNRYASNIVESAYLILNEWKNNIQSDLIKKVTNYLVDGNG
RFVFTDITLPNIAEQYTHQDEIYEQVHSKGLYVPESRSILLHGPSKGVELRNDSEGFIHE
FGHAVDDYAGYLLDKNQSDLVTNSKKFIDIFKEEGSNLTSYGRTNEAEFFAEAFRLMHST
DHAERLKVQKNAPKTFQFINDQIKFIINS
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BDBM8503 |
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Peptide Substrate |
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Name: | Peptide Substrate |
Synonyms: | (Cou)Consensus(K(QSY-35)GG)-NH2 |
Type: | Peptide |
Mol. Mass.: | 9139.37 |
Organism: | n/a |
Description: | n/a |
Residue: | 78 |
Sequence: | HYDRYMETHYLACETYLCMARINYLNLEKKKKVLPIQLNAATDKNNITRENADIALYLAM
INPHENYLACETYLGGNH
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