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TargetPlasma kallikrein
LigandBDBM306371
Substrate/Competitorn/a
Meas. Tech.In Vitro Plasma Kallikrein Inhibition Assay
IC50 4.79±n/a nM
Citation Li, ZZancanella, MYu, CSetti, LQSham, HXu, QYee, CWYu, M Bridged bicyclic kallikrein inhibitors US Patent US10144746 Publication Date 12/4/2018
More Info.:Get all data from this article,  Assay Method
 
Plasma kallikrein
Name:Plasma kallikrein
Synonyms:Fletcher factor | KLK3 | KLKB1 | KLKB1_HUMAN | Kallikrein | Kininogenin | Plasma kallikrein heavy chain | Plasma kallikrein light chain | Plasma prekallikrein
Type:Protein
Mol. Mass.:71391.16
Organism:Homo sapiens (Human)
Description:P03952
Residue:638
Sequence:
MILFKQATYFISLFATVSCGCLTQLYENAFFRGGDVASMYTPNAQYCQMRCTFHPRCLLF
SFLPASSINDMEKRFGCFLKDSVTGTLPKVHRTGAVSGHSLKQCGHQISACHRDIYKGVD
MRGVNFNVSKVSSVEECQKRCTSNIRCQFFSYATQTFHKAEYRNNCLLKYSPGGTPTAIK
VLSNVESGFSLKPCALSEIGCHMNIFQHLAFSDVDVARVLTPDAFVCRTICTYHPNCLFF
TFYTNVWKIESQRNVCLLKTSESGTPSSSTPQENTISGYSLLTCKRTLPEPCHSKIYPGV
DFGGEELNVTFVKGVNVCQETCTKMIRCQFFTYSLLPEDCKEEKCKCFLRLSMDGSPTRI
AYGTQGSSGYSLRLCNTGDNSVCTTKTSTRIVGGTNSSWGEWPWQVSLQVKLTAQRHLCG
GSLIGHQWVLTAAHCFDGLPLQDVWRIYSGILNLSDITKDTPFSQIKEIIIHQNYKVSEG
NHDIALIKLQAPLNYTEFQKPICLPSKGDTSTIYTNCWVTGWGFSKEKGEIQNILQKVNI
PLVTNEECQKRYQDYKITQRMVCAGYKEGGKDACKGDSGGPLVCKHNGMWRLVGITSWGE
GCARREQPGVYTKVAEYMDWILEKTQSSDGKAQMQSPA
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  Blast E-value cutoff:
BDBM306371
n/a
NameBDBM306371
Synonyms:(+-)-N-[(6-amino-2,4- dimethylpyridin-3-yl)- methyl]-12-[(1H- pyrazol-1-yl)(2H2)methyl]-15- oxatetracyclo[6.6.1.02,7.09,14] pentadeca-2,4,6,9,11,13- hexaene-4-carboxamide | US10144746, Compound 13
TypeSmall organic molecule
Emp. Form.C27H27N5O2
Mol. Mass.453.5356
SMILESCc1cc(N)nc(C)c1CNC(=O)c1ccc2C3OC(c4cc(CN5CCC=N5)ccc34)c2c1 |c:28|
Structure
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