| Reaction Details |
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 | Report a problem with these data |
| Target | Plasma kallikrein |
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| Ligand | BDBM306528 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Plasma Kallikrein Inhibition Assay |
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| IC50 | 1.000±n/a nM |
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| Citation |  Li, Z; Zancanella, M; Yu, C; Setti, LQ; Sham, H; Xu, Q; Yee, CW; Yu, M Bridged bicyclic kallikrein inhibitors US Patent US10144746 Publication Date 12/4/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Plasma kallikrein |
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| Name: | Plasma kallikrein |
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| Synonyms: | Fletcher factor | KLK3 | KLKB1 | KLKB1_HUMAN | Kallikrein | Kininogenin | Plasma kallikrein heavy chain | Plasma kallikrein light chain | Plasma prekallikrein |
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| Type: | Protein |
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| Mol. Mass.: | 71391.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P03952 |
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| Residue: | 638 |
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| Sequence: | MILFKQATYFISLFATVSCGCLTQLYENAFFRGGDVASMYTPNAQYCQMRCTFHPRCLLF
SFLPASSINDMEKRFGCFLKDSVTGTLPKVHRTGAVSGHSLKQCGHQISACHRDIYKGVD
MRGVNFNVSKVSSVEECQKRCTSNIRCQFFSYATQTFHKAEYRNNCLLKYSPGGTPTAIK
VLSNVESGFSLKPCALSEIGCHMNIFQHLAFSDVDVARVLTPDAFVCRTICTYHPNCLFF
TFYTNVWKIESQRNVCLLKTSESGTPSSSTPQENTISGYSLLTCKRTLPEPCHSKIYPGV
DFGGEELNVTFVKGVNVCQETCTKMIRCQFFTYSLLPEDCKEEKCKCFLRLSMDGSPTRI
AYGTQGSSGYSLRLCNTGDNSVCTTKTSTRIVGGTNSSWGEWPWQVSLQVKLTAQRHLCG
GSLIGHQWVLTAAHCFDGLPLQDVWRIYSGILNLSDITKDTPFSQIKEIIIHQNYKVSEG
NHDIALIKLQAPLNYTEFQKPICLPSKGDTSTIYTNCWVTGWGFSKEKGEIQNILQKVNI
PLVTNEECQKRYQDYKITQRMVCAGYKEGGKDACKGDSGGPLVCKHNGMWRLVGITSWGE
GCARREQPGVYTKVAEYMDWILEKTQSSDGKAQMQSPA
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| BDBM306528 |
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| n/a |
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| Name | BDBM306528 |
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| Synonyms: | (+-)-N-[(4-carbamimidoylphenyl) methyl]-12-(2,4- difluorophenyl)-15-oxatetracyclo [6.6.1.02,7.09,14]-pentadeca- 2,4,6,9,11,13-hexaene- 4-carboxamide | US10144746, Compound 170 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H21F2N3O2 |
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| Mol. Mass. | 481.4927 |
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| SMILES | NC(=N)c1ccc(CNC(=O)c2ccc3C4OC(c3c2)c2cc(ccc42)-c2ccc(F)cc2F)cc1 |
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| Structure | 
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