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TargetEnoyl-[acyl-carrier-protein] reductase [NADH] FabI
LigandBDBM8734
Substrate/CompetitorBDBM8737
Meas. Tech.Enzyme Inhibition Assay
pH6.5±n/a
Temperature303.15±n/a K
IC50<60±n/a nM
Citation Seefeld, MAMiller, WHNewlander, KABurgess, WJDeWolf, WEElkins, PAHead, MSJakas, DRJanson, CAKeller, PMManley, PJMoore, TDPayne, DJPearson, SPolizzi, BJQiu, XRittenhouse, SFUzinskas, INWallis, NGHuffman, WF Indole naphthyridinones as inhibitors of bacterial enoyl-ACP reductases FabI and FabK. J Med Chem46:1627-35 (2003) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI
Name:Enoyl-[acyl-carrier-protein] reductase [NADH] FabI
Synonyms:Enoyl - (acyl carrier protein) reductase | Enoyl-ACP Reductase (FabI) | Enoyl-[acyl-carrier-protein] reductase | Enoyl-acyl carrier protein reductase (FabI) | FABI_ECOLI | NADH-dependent enoyl-ACP reductase | envM | fabI
Type:Enzyme
Mol. Mass.:27861.12
Organism:Escherichia coli
Description:n/a
Residue:262
Sequence:
MGFLSGKRILVTGVASKLSIAYGIAQAMHREGAELAFTYQNDKLKGRVEEFAAQLGSDIV
LQCDVAEDASIDTMFAELGKVWPKFDGFVHSIGFAPGDQLDGDYVNAVTREGFKIAHDIS
SYSFVAMAKACRSMLNPGSALLTLSYLGAERAIPNYNVMGLAKASLEANVRYMANAMGPE
GVRVNAISAGPIRTLAASGIKDFRKMLAHCEAVTPIRRTVTIEDVGNSAAFLCSDLSAGI
SGEVVHVDGGFSIAAMNELELK
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BDBM8734
BDBM8737
NameBDBM8734
Synonyms:(2E)-N-methyl-N-[(2-methyl-1H-indol-3-yl)methyl]-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)prop-2-enamide | (E)-N-Methyl-N-(2-methyl-1H-indol-3-ylmethyl)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamide | indole naphthyridinone 30
TypeSmall organic molecule
Emp. Form.C22H22N4O2
Mol. Mass.374.4357
SMILESCN(Cc1c(C)[nH]c2ccccc12)C(=O)\C=C\c1cnc2NC(=O)CCc2c1
Structure
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