| Reaction Details |
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 | Report a problem with these data |
| Target | Enoyl-[acyl-carrier-protein] reductase [NADH] FabI |
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| Ligand | BDBM8748 |
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| Substrate/Competitor | BDBM8737 |
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| Meas. Tech. | Enzyme Inhibition Assay |
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| Temperature | 303.15±n/a K |
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| IC50 | 1180±n/a nM |
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| Comments | extracted |
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| Citation |  Heerding, DA; Chan, G; DeWolf, WE; Fosberry, AP; Janson, CA; Jaworski, DD; McManus, E; Miller, WH; Moore, TD; Payne, DJ; Qiu, X; Rittenhouse, SF; Slater-Radosti, C; Smith, W; Takata, DT; Vaidya, KS; Yuan, CC; Huffman, WF 1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI). Bioorg Med Chem Lett11:2061-5 (2001) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Enoyl-[acyl-carrier-protein] reductase [NADH] FabI |
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| Name: | Enoyl-[acyl-carrier-protein] reductase [NADH] FabI |
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| Synonyms: | Enoyl - (acyl carrier protein) reductase | Enoyl-ACP Reductase (FabI) | Enoyl-[acyl-carrier-protein] reductase | Enoyl-acyl carrier protein reductase (FabI) | FABI_ECOLI | NADH-dependent enoyl-ACP reductase | envM | fabI |
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| Type: | Enzyme |
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| Mol. Mass.: | 27861.12 |
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| Organism: | Escherichia coli |
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| Description: | n/a |
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| Residue: | 262 |
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| Sequence: | MGFLSGKRILVTGVASKLSIAYGIAQAMHREGAELAFTYQNDKLKGRVEEFAAQLGSDIV
LQCDVAEDASIDTMFAELGKVWPKFDGFVHSIGFAPGDQLDGDYVNAVTREGFKIAHDIS
SYSFVAMAKACRSMLNPGSALLTLSYLGAERAIPNYNVMGLAKASLEANVRYMANAMGPE
GVRVNAISAGPIRTLAASGIKDFRKMLAHCEAVTPIRRTVTIEDVGNSAAFLCSDLSAGI
SGEVVHVDGGFSIAAMNELELK
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| BDBM8748 |
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| BDBM8737 |
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| Name | BDBM8748 |
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| Synonyms: | 1-[(4-phenylphenyl)methyl]-4-(thiophen-3-yl)-1H-imidazole | Disubstituted imidazole 27 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H16N2S |
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| Mol. Mass. | 316.419 |
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| SMILES | C(c1ccc(cc1)-c1ccccc1)n1cnc(c1)-c1ccsc1 |
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| Structure | 
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