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TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI
LigandBDBM8726
Substrate/CompetitorBDBM8737
Meas. Tech.Enzyme Inhibition Assay
Temperature303.15±n/a K
IC50 1100±n/a nM
Commentsextracted
Citation Seefeld, MA; Miller, WH; Newlander, KA; Burgess, WJ; Payne, DJ; Rittenhouse, SF; Moore, TD; DeWolf, WE; Keller, PM; Qiu, X; Janson, CA; Vaidya, K; Fosberry, AP; Smyth, MG; Jaworski, DD; Slater-Radosti, C; Huffman, WF Inhibitors of bacterial enoyl acyl carrier protein reductase (FabI): 2,9-disubstituted 1,2,3,4-tetrahydropyrido[3,4-b]indoles as potential antibacterial agents. Bioorg Med Chem Lett11:2241-4 (2001) [PubMed]  Article
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Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI
Name:Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI
Synonyms:Enoyl-ACP Reductase (FabI) | Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI | FABI_STAAR | NADPH-dependent enoyl-ACP reductase | fabI | trans-2-enoyl-[acyl carrier protein] reductase
Type:Enzyme
Mol. Mass.:27989.00
Organism:Staphylococcus aureus
Description:Q6GI75
Residue:256
Sequence:
MLNLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEA
HLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDI
SSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGP
DNIRVNAISAGPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSG
VTGENIHVDSGFHAIK
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BDBM8726
BDBM8737
NameBDBM8726
Synonyms:5-chloro-2-(2,4-dichlorophenoxy)phenol | CHEMBL849 | TCL | Triclosan | US20230414581, Compound 35
TypeSmall organic molecule
Emp. Form.C12H7Cl3O2
Mol. Mass.289.542
SMILESOc1cc(Cl)ccc1Oc1ccc(Cl)cc1Cl
Structure
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