| Reaction Details |
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 | Report a problem with these data |
| Target | Enoyl-[acyl-carrier-protein] reductase [NADH] FabI |
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| Ligand | BDBM8764 |
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| Substrate/Competitor | BDBM8737 |
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| Meas. Tech. | Enzyme Inhibition Assay |
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| Temperature | 303.15±n/a K |
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| IC50 | 26800±n/a nM |
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| Comments | extracted |
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| Citation |  Seefeld, MA; Miller, WH; Newlander, KA; Burgess, WJ; Payne, DJ; Rittenhouse, SF; Moore, TD; DeWolf, WE; Keller, PM; Qiu, X; Janson, CA; Vaidya, K; Fosberry, AP; Smyth, MG; Jaworski, DD; Slater-Radosti, C; Huffman, WF Inhibitors of bacterial enoyl acyl carrier protein reductase (FabI): 2,9-disubstituted 1,2,3,4-tetrahydropyrido[3,4-b]indoles as potential antibacterial agents. Bioorg Med Chem Lett11:2241-4 (2001) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Enoyl-[acyl-carrier-protein] reductase [NADH] FabI |
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| Name: | Enoyl-[acyl-carrier-protein] reductase [NADH] FabI |
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| Synonyms: | Enoyl - (acyl carrier protein) reductase | Enoyl-ACP Reductase (FabI) | Enoyl-[acyl-carrier-protein] reductase | Enoyl-acyl carrier protein reductase (FabI) | FABI_ECOLI | NADH-dependent enoyl-ACP reductase | envM | fabI |
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| Type: | Enzyme |
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| Mol. Mass.: | 27861.12 |
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| Organism: | Escherichia coli |
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| Description: | n/a |
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| Residue: | 262 |
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| Sequence: | MGFLSGKRILVTGVASKLSIAYGIAQAMHREGAELAFTYQNDKLKGRVEEFAAQLGSDIV
LQCDVAEDASIDTMFAELGKVWPKFDGFVHSIGFAPGDQLDGDYVNAVTREGFKIAHDIS
SYSFVAMAKACRSMLNPGSALLTLSYLGAERAIPNYNVMGLAKASLEANVRYMANAMGPE
GVRVNAISAGPIRTLAASGIKDFRKMLAHCEAVTPIRRTVTIEDVGNSAAFLCSDLSAGI
SGEVVHVDGGFSIAAMNELELK
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| BDBM8764 |
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| BDBM8737 |
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| Name | BDBM8764 |
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| Synonyms: | 1,2,3,4-Tetrahydropyrido[3,4-b]indole 9 | methyl 5-{2-[(4-hydroxyphenyl)carbonyl]-1H,2H,3H,4H,9H-pyrido[3,4-b]indol-9-yl}pentanoate |
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| Type | Small organic molecule |
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| Emp. Form. | C24H26N2O4 |
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| Mol. Mass. | 406.4742 |
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| SMILES | COC(=O)CCCCn1c2CN(CCc2c2ccccc12)C(=O)c1ccc(O)cc1 |
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| Structure | 
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