| Reaction Details |
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 | Report a problem with these data |
| Target | Interferon-induced, double-stranded RNA-activated protein kinase |
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| Ligand | BDBM308054 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | PDGFRβ Kinase Assay |
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| Ki | 99.0±n/a nM |
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| Citation |  Boral, S; Malone, TC; Wang, S; Rao, S; Yang, R Heterocycle-substituted pyridyl benzothiophenes as kinase inhibitors US Patent US9650366 Publication Date 5/16/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Interferon-induced, double-stranded RNA-activated protein kinase |
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| Name: | Interferon-induced, double-stranded RNA-activated protein kinase |
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| Synonyms: | E2AK2_HUMAN | EIF2AK2 | Eukaryotic translation initiation factor 2-alpha kinase 2 | Interferon-inducible RNA-dependent protein kinase | P1/eIF-2A protein kinase | PKR | PRKR | Protein kinase R | Protein kinase RNA-activated | Tyrosine-protein kinase EIF2AK2 | eIF-2A protein kinase 2 | p68 kinase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 62104.61 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1467743 |
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| Residue: | 551 |
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| Sequence: | MAGDLSAGFFMEELNTYRQKQGVVLKYQELPNSGPPHDRRFTFQVIIDGREFPEGEGRSK
KEAKNAAAKLAVEILNKEKKAVSPLLLTTTNSSEGLSMGNYIGLINRIAQKKRLTVNYEQ
CASGVHGPEGFHYKCKMGQKEYSIGTGSTKQEAKQLAAKLAYLQILSEETSVKSDYLSSG
SFATTCESQSNSLVTSTLASESSSEGDFSADTSEINSNSDSLNSSSLLMNGLRNNQRKAK
RSLAPRFDLPDMKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKY
NNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTK
CLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNI
FLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAE
LLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWK
KSPEKNERHTC
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| BDBM308054 |
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| n/a |
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| Name | BDBM308054 |
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| Synonyms: | US10011593, Ex. 4 | US9650366, 4 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H20F4N8O2S |
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| Mol. Mass. | 572.537 |
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| SMILES | Nc1ncc(cc1-c1cc2cc(NC(=O)Nc3ccc(F)c(c3)C(F)(F)F)ccc2s1)-c1nnn(CCCO)n1 |
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| Structure | 
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