| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Interferon-induced, double-stranded RNA-activated protein kinase |
|---|
| Ligand | BDBM308060 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | PDGFRβ Kinase Assay |
|---|
| Ki | 158±n/a nM |
|---|
| Citation |  Boral, S; Malone, TC; Wang, S; Rao, S; Yang, R Heterocycle-substituted pyridyl benzothiophenes as kinase inhibitors US Patent US9650366 Publication Date 5/16/2017 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Interferon-induced, double-stranded RNA-activated protein kinase |
|---|
| Name: | Interferon-induced, double-stranded RNA-activated protein kinase |
|---|
| Synonyms: | E2AK2_HUMAN | EIF2AK2 | Eukaryotic translation initiation factor 2-alpha kinase 2 | Interferon-inducible RNA-dependent protein kinase | P1/eIF-2A protein kinase | PKR | PRKR | Protein kinase R | Protein kinase RNA-activated | Tyrosine-protein kinase EIF2AK2 | eIF-2A protein kinase 2 | p68 kinase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 62104.61 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1467743 |
|---|
| Residue: | 551 |
|---|
| Sequence: | MAGDLSAGFFMEELNTYRQKQGVVLKYQELPNSGPPHDRRFTFQVIIDGREFPEGEGRSK
KEAKNAAAKLAVEILNKEKKAVSPLLLTTTNSSEGLSMGNYIGLINRIAQKKRLTVNYEQ
CASGVHGPEGFHYKCKMGQKEYSIGTGSTKQEAKQLAAKLAYLQILSEETSVKSDYLSSG
SFATTCESQSNSLVTSTLASESSSEGDFSADTSEINSNSDSLNSSSLLMNGLRNNQRKAK
RSLAPRFDLPDMKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKY
NNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTK
CLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNI
FLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAE
LLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWK
KSPEKNERHTC
|
|
|
|---|
| BDBM308060 |
|---|
| n/a |
|---|
| Name | BDBM308060 |
|---|
| Synonyms: | US10011593, Ex. 11 | US9650366, 11 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H20ClF3N8O2 |
|---|
| Mol. Mass. | 556.927 |
|---|
| SMILES | Nc1ncc(cc1C#Cc1cccc(NC(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)c1)-c1nnn(CCCO)n1 |
|---|
| Structure | 
|
|---|
Search and Browse
