| Reaction Details |
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 | Report a problem with these data |
| Target | Proto-oncogene tyrosine-protein kinase Src |
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| Ligand | BDBM8807 |
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| Substrate/Competitor | poly-Glu-Ala-Tyr |
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| Meas. Tech. | Homogeneous Time-resolved Fluorescence (HTRF) Assay |
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| IC50 | 43±n/a nM |
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| Citation |  Burchat, AF; Calderwood, DJ; Friedman, MM; Hirst, GC; Li, B; Rafferty, P; Ritter, K; Skinner, BS Pyrazolo[3,4-d]pyrimidines containing an extended 3-substituent as potent inhibitors of Lck - a selectivity insight. Bioorg Med Chem Lett12:1687-90 (2002) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| |
| Proto-oncogene tyrosine-protein kinase Src |
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| Name: | Proto-oncogene tyrosine-protein kinase Src |
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| Synonyms: | Calmodulin/Proto-oncogene tyrosine-protein kinase Src | Protein cereblon/Tyrosine-protein kinase SRC | Proto-oncogene c-Src | Proto-oncogene tyrosine-protein kinase Src (c-Src) | SRC | SRC1 | SRC_HUMAN | Tyrosine-protein kinase Src (SRC) | V-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | c-Src | p60-Src | pp60c-src |
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| Type: | Protein |
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| Mol. Mass.: | 59838.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P12931 |
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| Residue: | 536 |
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| Sequence: | MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAE
PKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGD
WWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRES
ETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGL
CHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTL
KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKY
LRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYT
ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER
GYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
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| BDBM8807 |
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| poly-Glu-Ala-Tyr |
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| Name: | poly-Glu-Ala-Tyr |
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| Synonyms: | poly-Glu-Ala-Tyr-biotin |
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| Type: | Random Copolymer |
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| Mol. Mass.: | 358.43 |
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| Organism: | n/a |
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| Description: | It is a synthetic polymer of glutamic acid, alanine and
tyrosine (poly-Glu-Ala-Tyr) that has been biotinylated. |
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| Residue: | 3 |
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| Sequence: | |
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