Reaction Details | |||
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Target | Tyrosine-protein kinase receptor TYRO3 | ||
Ligand | BDBM308369 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Activity Assay | ||
IC50 | 24.0±n/a nM | ||
Citation | Wang, X; Zhang, W; Frye, S Therapeutic uses of selected pyrimidine compounds with anti-Mer tyrosine kinase activity US Patent US9649309 Publication Date 5/16/2017 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase receptor TYRO3 | |||
Name: | Tyrosine-protein kinase receptor TYRO3 | ||
Synonyms: | BYK | DTK | RSE | SKY | TIF | TYRO3 | TYRO3_HUMAN | Tyrosine-protein kinase SKY | ||
Type: | Protein | ||
Mol. Mass.: | 96894.13 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q06418 | ||
Residue: | 890 | ||
Sequence: |
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BDBM308369 | |||
n/a | |||
Name | BDBM308369 | ||
Synonyms: | US9649309, Compound UNC4358A | ||
Type | Small organic molecule | ||
Emp. Form. | C27H40N6O | ||
Mol. Mass. | 464.6461 | ||
SMILES | CCCCNc1ncc(c(N[C@H]2CC[C@H](O)CC2)n1)-c1ccc(cn1)C1=CCN(CC1)C(C)C |r,wU:11.10,wD:14.14,t:28,(-10,-4.62,;-8.67,-3.85,;-7.34,-4.62,;-6,-3.85,;-4.67,-4.62,;-3.33,-3.85,;-2,-4.62,;-.67,-3.85,;-.67,-2.31,;-2,-1.54,;-2,,;-3.33,.77,;-4.67,,;-6,.77,;-6,2.31,;-7.34,3.08,;-4.67,3.08,;-3.33,2.31,;-3.33,-2.31,;.67,-1.54,;2,-2.31,;3.33,-1.54,;3.33,,;2,.77,;.67,,;4.67,.77,;4.67,2.31,;6,3.08,;7.34,2.31,;7.34,.77,;6,,;8.67,3.08,;10,2.31,;8.67,4.62,)| | ||
Structure |