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TargetAlpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
LigandBDBM309253
Substrate/Competitorn/a
Meas. Tech.Radioligand Binding Assay
Ki<10.00±n/a nM
Citation Amberg, WPohlki, FLange, UWang, YXZhao, HHLi, HBrewer, JTZanze, IDietrich, JVasudevan, ADjuric, SWLao, YHutchins, CW Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy US Patent US9656955 Publication Date 5/23/2017
More Info.:Get all data from this article,  Assay Method
 
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Name:Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Synonyms:GGNT1 | GLCT1 | GLYT1 | GNT-I | GlcNAc-T I | MGAT | MGAT1 | MGAT1_HUMAN | N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I
Type:PROTEIN
Mol. Mass.:50891.32
Organism:Homo sapiens (Human)
Description:ChEMBL_107587
Residue:445
Sequence:
MLKKQSAGLVLWGAILFVAWNALLLLFFWTRPAPGRPPSVSALDGDPASLTREVIRLAQD
AEVELERQRGLLQQIGDALSSQRGRVPTAAPPAQPRVPVTPAPAVIPILVIACDRSTVRR
CLDKLLHYRPSAELFPIIVSQDCGHEETAQAIASYGSAVTHIRQPDLSSIAVPPDHRKFQ
GYYKIARHYRWALGQVFRQFRFPAAVVVEDDLEVAPDFFEYFRATYPLLKADPSLWCVSA
WNDNGKEQMVDASRPELLYRTDFFPGLGWLLLAELWAELEPKWPKAFWDDWMRRPEQRQG
RACIRPEISRTMTFGRKGVSHGQFFDQHLKFIKLNQQFVHFTQLDLSYLQREAYDRDFLA
RVYGAPQLQVEKVRTNDRKELGEVRVQYTGRDSFKAFAKALGVMDDLKSGVPRAGYRGIV
TFQFRGRRVHLAPPLTWEGYDPSWN
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  Blast E-value cutoff:
BDBM309253
n/a
NameBDBM309253
Synonyms:4-(benzyloxy)-5-fluoro-N-{(3R,4S)-1-[(1-methyl-1H-imidazol-4-yl)sulfonyl]-4-phenylpyrrolidin-3-yl}pyridin-2-amine | US9656955, Example 776
TypeSmall Organic Molecule
Emp. Form.C26H26FN5O3S
Mol. Mass.507.58
SMILESCn1cnc(c1)S(=O)(=O)N1C[C@H](Nc2cc(OCc3ccccc3)c(F)cn2)[C@H](C1)c1ccccc1
Structure
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