| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase |
|---|
| Ligand | BDBM309278 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Radioligand Binding Assay |
|---|
| Ki | <10.00±n/a nM |
|---|
| Citation |  Amberg, W; Pohlki, F; Lange, U; Wang, YX; Zhao, HH; Li, H; Brewer, JT; Zanze, I; Dietrich, J; Vasudevan, A; Djuric, SW; Lao, Y; Hutchins, CW Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy US Patent US9656955 Publication Date 5/23/2017 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase |
|---|
| Name: | Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase |
|---|
| Synonyms: | GGNT1 | GLCT1 | GLYT1 | GNT-I | GlcNAc-T I | MGAT | MGAT1 | MGAT1_HUMAN | N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 50891.32 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_107587 |
|---|
| Residue: | 445 |
|---|
| Sequence: | MLKKQSAGLVLWGAILFVAWNALLLLFFWTRPAPGRPPSVSALDGDPASLTREVIRLAQD
AEVELERQRGLLQQIGDALSSQRGRVPTAAPPAQPRVPVTPAPAVIPILVIACDRSTVRR
CLDKLLHYRPSAELFPIIVSQDCGHEETAQAIASYGSAVTHIRQPDLSSIAVPPDHRKFQ
GYYKIARHYRWALGQVFRQFRFPAAVVVEDDLEVAPDFFEYFRATYPLLKADPSLWCVSA
WNDNGKEQMVDASRPELLYRTDFFPGLGWLLLAELWAELEPKWPKAFWDDWMRRPEQRQG
RACIRPEISRTMTFGRKGVSHGQFFDQHLKFIKLNQQFVHFTQLDLSYLQREAYDRDFLA
RVYGAPQLQVEKVRTNDRKELGEVRVQYTGRDSFKAFAKALGVMDDLKSGVPRAGYRGIV
TFQFRGRRVHLAPPLTWEGYDPSWN
|
|
|
|---|
| BDBM309278 |
|---|
| n/a |
|---|
| Name | BDBM309278 |
|---|
| Synonyms: | (3R,4S)-4-(4-fluorophenyl)-1-[(1-methyl-1H-imidazol-4-yl)sulfonyl]-N-[3-(pyridin-2-yl)phenyl]pyrrolidin-3-amine | BDBM309279 | US9656955, Example 801 |
|---|
| Type | Small Organic Molecule |
|---|
| Emp. Form. | C25H25N5O2S |
|---|
| Mol. Mass. | 459.563 |
|---|
| SMILES | Cn1cnc(c1)S(=O)(=O)N1C[C@H](Nc2cccc(c2)-c2ccccn2)[C@H](C1)c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
