| Reaction Details |
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 | Report a problem with these data |
| Target | Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase |
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| Ligand | BDBM309286 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Radioligand Binding Assay |
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| Ki | <10.00±n/a nM |
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| Citation |  Amberg, W; Pohlki, F; Lange, U; Wang, YX; Zhao, HH; Li, H; Brewer, JT; Zanze, I; Dietrich, J; Vasudevan, A; Djuric, SW; Lao, Y; Hutchins, CW Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy US Patent US9656955 Publication Date 5/23/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase |
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| Name: | Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase |
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| Synonyms: | GGNT1 | GLCT1 | GLYT1 | GNT-I | GlcNAc-T I | MGAT | MGAT1 | MGAT1_HUMAN | N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I |
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| Type: | PROTEIN |
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| Mol. Mass.: | 50891.32 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_107587 |
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| Residue: | 445 |
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| Sequence: | MLKKQSAGLVLWGAILFVAWNALLLLFFWTRPAPGRPPSVSALDGDPASLTREVIRLAQD
AEVELERQRGLLQQIGDALSSQRGRVPTAAPPAQPRVPVTPAPAVIPILVIACDRSTVRR
CLDKLLHYRPSAELFPIIVSQDCGHEETAQAIASYGSAVTHIRQPDLSSIAVPPDHRKFQ
GYYKIARHYRWALGQVFRQFRFPAAVVVEDDLEVAPDFFEYFRATYPLLKADPSLWCVSA
WNDNGKEQMVDASRPELLYRTDFFPGLGWLLLAELWAELEPKWPKAFWDDWMRRPEQRQG
RACIRPEISRTMTFGRKGVSHGQFFDQHLKFIKLNQQFVHFTQLDLSYLQREAYDRDFLA
RVYGAPQLQVEKVRTNDRKELGEVRVQYTGRDSFKAFAKALGVMDDLKSGVPRAGYRGIV
TFQFRGRRVHLAPPLTWEGYDPSWN
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| BDBM309286 |
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| n/a |
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| Name | BDBM309286 |
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| Synonyms: | 5-fluoro-N-{(3R,4S)-4-(4-fluorophenyl)-1-[(1-methyl-1H-imidazol-4-yl)sulfonyl]pyrrolidin-3-yl}-4-(2,2,2-trifluoroethoxy)pyridin-2-amine | US9656955, Example 810 |
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| Type | Small Organic Molecule |
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| Emp. Form. | C21H20F5N5O3S |
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| Mol. Mass. | 517.472 |
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| SMILES | Cn1cnc(c1)S(=O)(=O)N1C[C@H](Nc2cc(OCC(F)(F)F)c(F)cn2)[C@H](C1)c1ccc(F)cc1 |
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| Structure | 
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