Reaction Details |
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Target | Cytochrome P450 11B1, mitochondrial |
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Ligand | BDBM8871 |
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Substrate/Competitor | BDBM8582 |
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Meas. Tech. | CYP11B Assay |
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pH | 7.4±n/a |
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Temperature | 310.15±n/a K |
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IC50 | 3.3±n/a nM |
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Citation | Ulmschneider, S; Muller-Vieira, U; Mitrenga, M; Hartmann, RW; Oberwinkler-Marchais, S; Klein, CD; Bureik, M; Bernhardt, R; Antes, I; Lengauer, T Synthesis and evaluation of imidazolylmethylenetetrahydronaphthalenes and imidazolylmethyleneindanes: potent inhibitors of aldosterone synthase. J Med Chem48:1796-805 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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Cytochrome P450 11B1, mitochondrial |
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Name: | Cytochrome P450 11B1, mitochondrial |
Synonyms: | C11B1_HUMAN | CYP11B1 | CYPXIB1 | Cytochrome P450 11B, mitochondrial precursor | Cytochrome P450 11B1 | Cytochrome P450 11B1 (CYP11B1) | Cytochrome P450 11B1, mitochondrial | S11BH |
Type: | Enzyme |
Mol. Mass.: | 57591.44 |
Organism: | Homo sapiens (Human) |
Description: | P15538 |
Residue: | 503 |
Sequence: | MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQG
YEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYR
QHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNA
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
PRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELS
PDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATT
ELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRP
ERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQED
IKMVYSFILRPSMFPLLTFRAIN
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BDBM8871 |
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BDBM8582 |
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Name | BDBM8871 |
Synonyms: | 5-[(1E)-1,2,3,4-tetrahydronaphthalen-1-ylidenemethyl]-1H-imidazole | 5-[(E)-3,4-Dihydronaphthalen-1(2H)-ylidenemethyl]-1H-imidazole | Imidazolylmethylenetetrahydronaphthalene 1a | Imidazolylmethylenetetrahydronaphthalene 1b |
Type | Small organic molecule |
Emp. Form. | C14H14N2 |
Mol. Mass. | 210.2744 |
SMILES | C1CC(=Cc2cnc[nH]2)c2ccccc2C1 |w:3.3| |
Structure |
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