Reaction Details |
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Target | Cytochrome P450 11B1, mitochondrial |
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Ligand | BDBM8892 |
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Substrate/Competitor | BDBM8582 |
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Meas. Tech. | CYP11B Assay |
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pH | 7.4±n/a |
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Temperature | 310.15±n/a K |
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IC50 | 1268±n/a nM |
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Citation | Voets, M; Antes, I; Scherer, C; Muller-Vieira, U; Biemel, K; Marchais-Oberwinkler, S; Hartmann, RW Synthesis and evaluation of heteroaryl-substituted dihydronaphthalenes and indenes: potent and selective inhibitors of aldosterone synthase (CYP11B2) for the treatment of congestive heart failure and myocardial fibrosis. Pharmacol Rev49:2222-31 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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Cytochrome P450 11B1, mitochondrial |
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Name: | Cytochrome P450 11B1, mitochondrial |
Synonyms: | C11B1_HUMAN | CYP11B1 | CYPXIB1 | Cytochrome P450 11B, mitochondrial precursor | Cytochrome P450 11B1 | Cytochrome P450 11B1 (CYP11B1) | Cytochrome P450 11B1, mitochondrial | S11BH |
Type: | Enzyme |
Mol. Mass.: | 57591.44 |
Organism: | Homo sapiens (Human) |
Description: | P15538 |
Residue: | 503 |
Sequence: | MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQG
YEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYR
QHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNA
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
PRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELS
PDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATT
ELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRP
ERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQED
IKMVYSFILRPSMFPLLTFRAIN
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BDBM8892 |
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BDBM8582 |
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Name | BDBM8892 |
Synonyms: | 3-(1-Methyl-3,4-dihydronaphthalen-2-yl)-pyridine | 3-(1-methyl-3,4-dihydronaphthalen-2-yl)pyridine | Dihydronaphthalene 6 | US9271963, 38 |
Type | Small organic molecule |
Emp. Form. | C16H15N |
Mol. Mass. | 221.297 |
SMILES | CC1=C(CCc2ccccc12)c1cccnc1 |t:1| |
Structure |
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