| Reaction Details |
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 | Report a problem with these data |
| Target | Steroid 17-alpha-hydroxylase/17,20 lyase |
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| Ligand | BDBM8892 |
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| Substrate/Competitor | BDBM8903 |
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| Meas. Tech. | CYP17 Assay |
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| IC50 | 1085±n/a nM |
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| Citation |  Voets, M; Antes, I; Scherer, C; Muller-Vieira, U; Biemel, K; Marchais-Oberwinkler, S; Hartmann, RW Synthesis and evaluation of heteroaryl-substituted dihydronaphthalenes and indenes: potent and selective inhibitors of aldosterone synthase (CYP11B2) for the treatment of congestive heart failure and myocardial fibrosis. Pharmacol Rev49:2222-31 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Steroid 17-alpha-hydroxylase/17,20 lyase |
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| Name: | Steroid 17-alpha-hydroxylase/17,20 lyase |
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| Synonyms: | CP17A_HUMAN | CYP17 | CYP17A1 | CYPXVII | Cytochrome P450 17A1 | Cytochrome P450 C17 (CYP17 ) | Cytochrome P450 C17 (CYP17) | Cytochrome P450 CYP17 | Cytochrome P450-C17 | Cytochrome P450-C17 (CYP17) | P450-C17 | S17AH | Steroid 17-alpha-Monooxygenase (CYP17) | Steroid 17-alpha-hydroxylase/17,20 lyase | Steroid 17-alpha-monooxygenase | cytochrome P450 monooxygenase 17 alpha hydroxylase/17,20-lyase (CYP17) |
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| Type: | Enzyme |
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| Mol. Mass.: | 57382.42 |
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| Organism: | Homo sapiens (Human) |
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| Description: | E.coli expressing human CYP17 |
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| Residue: | 508 |
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| Sequence: | MWELVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKY
GPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAH
WQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVIS
LICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRN
DLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIF
GAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREV
LRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNP
AGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIP
KVVFLIDSFKVKIKVRQAWREAQAEGST
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| BDBM8892 |
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| BDBM8903 |
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| Name | BDBM8892 |
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| Synonyms: | 3-(1-Methyl-3,4-dihydronaphthalen-2-yl)-pyridine | 3-(1-methyl-3,4-dihydronaphthalen-2-yl)pyridine | Dihydronaphthalene 6 | US9271963, 38 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H15N |
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| Mol. Mass. | 221.297 |
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| SMILES | CC1=C(CCc2ccccc12)c1cccnc1 |t:1| |
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| Structure | 
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