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TargetProteinase-activated receptor 4
LigandBDBM175995
Substrate/Competitorn/a
Meas. Tech.FLIPR Assay
Temperature298.15±n/a K
EC50 0.32±n/a nM
Commentsextracted
Citation Banville, JRémillard, RRuediger, EHDeon, DHGagnon, MDubé, LGuy, JPriestley, ESPosy, SLMaxwell, BDWong, PCLawrence, RMMiller, MM Imidazothiadiazole and imidazopyrazine derivatives as protease activated receptor 4 (PAR4) inhibitors for treating platelet aggregation US Patent US9688695 Publication Date 6/27/2017
More Info.:Get all data from this article,  Assay Method
 
Proteinase-activated receptor 4
Name:Proteinase-activated receptor 4
Synonyms:Coagulation factor II receptor-like 3 | F2RL3 | PAR-4 | PAR4 | PAR4_HUMAN | Proteinase-activated receptor 4 | Proteinase-activated receptor 4 (PAR4) | Thrombin receptor-like 3
Type:Protein
Mol. Mass.:41145.16
Organism:Homo sapiens (Human)
Description:Q96RI0
Residue:385
Sequence:
MWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDT
LELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAA
ADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVH
PLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASH
WQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSN
LLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSP
GDTVASKASAEGGSRGMGTHSSLLQ
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  Blast E-value cutoff:
BDBM175995
n/a
NameBDBM175995
Synonyms:US10047103, 75 | US9605024, Example 28 | US9688695, 28 | US9688695, 75
TypeSmall organic molecule
Emp. Form.C23H17N5O4S2
Mol. Mass.491.542
SMILESCOc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)-c3ccncc3)cc(OC)cc2o1
Structure
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