Reaction Details | |||
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Target | Histone-lysine N-methyltransferase EZH2 [Y641F] | ||
Ligand | BDBM310800 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Wild-Type PRC2 Enzyme Assay | ||
IC50 | 1.000±n/a nM | ||
Citation | Campbell, JE Substituted benzene compounds US Patent US10150764 Publication Date 12/11/2018 | ||
More Info.: | Get all data from this article, Assay Method | ||
Histone-lysine N-methyltransferase EZH2 [Y641F] | |||
Name: | Histone-lysine N-methyltransferase EZH2 [Y641F] | ||
Synonyms: | EZH2 | EZH2(Y641F) | EZH2_HUMAN | Histone-lysine N-methyltransferase EZH2 (Y641F) | KMT6 | ||
Type: | n/a | ||
Mol. Mass.: | 85351.84 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q15910[Y641F] | ||
Residue: | 746 | ||
Sequence: |
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BDBM310800 | |||
n/a | |||
Name | BDBM310800 | ||
Synonyms: | US10150764, Compound 86 | ||
Type | Small organic molecule | ||
Emp. Form. | C24H36ClN5O3 | ||
Mol. Mass. | 478.027 | ||
SMILES | CCN([C@H]1CC[C@@H](CC1)N(C)C)c1cc(Cl)cc(C(=O)NCc2c(OC)n(C)[nH]c2=O)c1C |r,wU:6.9,wD:3.2,(-2.82,.13,;-2.82,1.67,;-1.48,2.44,;-1.48,3.98,;-.15,4.75,;-.15,6.29,;-1.48,7.06,;-2.82,6.29,;-2.82,4.75,;-1.48,8.6,;-.15,9.37,;-2.82,9.37,;-.15,1.67,;1.18,2.44,;2.52,1.67,;3.85,2.44,;2.52,.13,;1.18,-.64,;1.18,-2.18,;2.52,-2.95,;-.15,-2.95,;-.15,-4.49,;-1.48,-5.26,;-1.48,-6.8,;-.39,-7.89,;-.79,-9.37,;-2.95,-7.27,;-3.72,-8.61,;-3.85,-6.03,;-2.95,-4.78,;-3.72,-3.45,;-.15,.13,;-1.48,-.64,)| | ||
Structure |