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TargetDimer of Gag-Pol polyprotein [489-587,Q496K]
LigandBDBM9124
Substrate/CompetitorHIV Protease Peptide Substrate
Meas. Tech.Protease Inhibition Assay
pH5.5±n/a
Temperature303.15±n/a K
IC50 0.46±n/a nM
Citation Kevin, NJDuffy, JLKirk, BAChapman, KTSchleif, WAOlsen, DBStahlhut, MRutkowski, CAKuo, LCJin, LLin, JHEmini, EATata, JR Novel HIV-1 protease inhibitors active against multiple PI-resistant viral strains: coadministration with indinavir. Bioorg Med Chem Lett13:4027-30 (2003) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Dimer of Gag-Pol polyprotein [489-587,Q496K]
Name:Dimer of Gag-Pol polyprotein [489-587,Q496K]
Synonyms:HIV-1 Protease | HIV-1 Protease NL4-3 | HIV-1 protease wild-type
Type:Protein Complex
Mol. Mass.:n/a
Description:n/a
Components:This complex has 2 components.
Component 1
Name:Gag-Pol polyprotein [489-587,Q496K]
Synonyms:HIV-1 Protease Chain A | HIV-1 Protease NL4-3 | POL_HV1N5 | gag-pol
Type:Enzyme Subunit
Mol. Mass.:10823.26
Organism:Human immunodeficiency virus type 1
Description:P12497[489-587,Q496K]
Residue:99
Sequence:
PQITLWKRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
Component 2
Name:Gag-Pol polyprotein [489-587,Q496K]
Synonyms:HIV-1 Protease Chain A | HIV-1 Protease NL4-3 | POL_HV1N5 | gag-pol
Type:Enzyme Subunit
Mol. Mass.:10823.26
Organism:Human immunodeficiency virus type 1
Description:P12497[489-587,Q496K]
Residue:99
Sequence:
PQITLWKRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM9124
HIV Protease Peptide Substrate
Name:HIV Protease Peptide Substrate
Synonyms:HIV Protease Substrate
Type:Peptide
Mol. Mass.:2715.95
Organism:n/a
Description:n/a
Residue:25
Sequence:
VSQN-(beta-naphthylalanine)-PIV