Reaction Details |
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Target | Dimer of Gag-Pol polyprotein [489-587,Q496K,L499I,M525I,N526D,M535I,R546K,L552P,A560V,G562S,I573V,L579M,I582L] |
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Ligand | BDBM9121 |
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Substrate/Competitor | HIV Protease Peptide Substrate |
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Meas. Tech. | Protease Inhibition Assay |
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IC50 | 0.15±n/a nM |
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Citation | Kevin, NJ; Duffy, JL; Kirk, BA; Chapman, KT; Schleif, WA; Olsen, DB; Stahlhut, M; Rutkowski, CA; Kuo, LC; Jin, L; Lin, JH; Emini, EA; Tata, JR Novel HIV-1 protease inhibitors active against multiple PI-resistant viral strains: coadministration with indinavir. Bioorg Med Chem Lett13:4027-30 (2003) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Dimer of Gag-Pol polyprotein [489-587,Q496K,L499I,M525I,N526D,M535I,R546K,L552P,A560V,G562S,I573V,L579M,I582L] |
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Name: | Dimer of Gag-Pol polyprotein [489-587,Q496K,L499I,M525I,N526D,M535I,R546K,L552P,A560V,G562S,I573V,L579M,I582L] |
Synonyms: | HIV-1 Protease Mutant (L10I/M36I/N37D/M46I/R57K/L63P/A71V/G73S/I84V/L90M/I93L) | HIV-1 Protease Mutant V-18C |
Type: | Protein Complex |
Mol. Mass.: | n/a |
Description: | n/a |
Components: | This complex has 2 components. |
Component 1 |
Name: | Gag-Pol polyprotein [489-587,Q496K,L499I,M525I,N526D,M535I,R546K,L552P,A560V,G562S,I573V,L579M,I582L] |
Synonyms: | HIV-1 Protease Mutant V-18C Chain A | HIV-1 Protease Mutant V-18C Chain B | POL_HV1N5 | gag-pol |
Type: | Enzyme Subunit |
Mol. Mass.: | 10805.20 |
Organism: | Human immunodeficiency virus type 1 |
Description: | L10I/M36I/N37D/M46I/R57K/L63P/A71V/G73S/I84V/L90M/I93L |
Residue: | 99 |
Sequence: | PQITLWKRPIVTIKIGGQLKEALLDTGADDTVLEEIDLPGRWKPKIIGGIGGFIKVKQYD
QIPIEICGHKVISTVLVGPTPVNVIGRNLMTQLGCTLNF
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Component 2 |
Name: | Gag-Pol polyprotein [489-587,Q496K,L499I,M525I,N526D,M535I,R546K,L552P,A560V,G562S,I573V,L579M,I582L] |
Synonyms: | HIV-1 Protease Mutant V-18C Chain A | HIV-1 Protease Mutant V-18C Chain B | POL_HV1N5 | gag-pol |
Type: | Enzyme Subunit |
Mol. Mass.: | 10805.20 |
Organism: | Human immunodeficiency virus type 1 |
Description: | L10I/M36I/N37D/M46I/R57K/L63P/A71V/G73S/I84V/L90M/I93L |
Residue: | 99 |
Sequence: | PQITLWKRPIVTIKIGGQLKEALLDTGADDTVLEEIDLPGRWKPKIIGGIGGFIKVKQYD
QIPIEICGHKVISTVLVGPTPVNVIGRNLMTQLGCTLNF
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BDBM9121 |
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HIV Protease Peptide Substrate |
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Name: | HIV Protease Peptide Substrate |
Synonyms: | HIV Protease Substrate |
Type: | Peptide |
Mol. Mass.: | 2715.95 |
Organism: | n/a |
Description: | n/a |
Residue: | 25 |
Sequence: | VSQN-(beta-naphthylalanine)-PIV
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