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TargetHIV-1 Protease Mutant Q-60C
LigandBDBM9121
Substrate/CompetitorHIV Protease Peptide Substrate
Meas. Tech.Protease Inhibition Assay
IC50 0.07±n/a nM
Citation Kevin NJDuffy JLKirk BAChapman KTSchleif WAOlsen DBStahlhut MRutkowski CAKuo LCJin LLin JHEmini EATata JR Novel HIV-1 protease inhibitors active against multiple PI-resistant viral strains: coadministration with indinavir. Bioorg Med Chem Lett 13:4027-30 (2003) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
HIV-1 Protease Mutant Q-60C
Name:HIV-1 Protease Mutant Q-60C
Synonyms:HIV-1 Protease Mutant (L10I/N37S/R41K/M46I/I54V/I62V/L63P/A71V/V77I/V82A/L90M/I93L)
Type:Protein Complex
Mol. Mass.:n/a
Description:n/a
Components:This complex has 2 components.
Component 1
Name:HIV-1 Protease Mutant Q-60C Chain A
Synonyms:HIV-1 Protease Mutant Q-60C Chain B
Type:Enzyme Subunit
Mol. Mass.:10738.15
Organism:Human immunodeficiency virus type 1
Description:L10I/N37S/R41K/M46I/I54V/I62V/L63P/A71V/V77I/V82A/L90M/I93L
Residue:99
Sequence:
PQITLWKRPIVTIKIGGQLKEALLDTGADDTVLEEMSLPGKWKPKIIGGIGGFVKVRQYD
QVPIEICGHKVIGTVLIGPTPANIIGRNLMTQLGCTLNF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
Component 2
Name:HIV-1 Protease Mutant Q-60C Chain A
Synonyms:HIV-1 Protease Mutant Q-60C Chain B
Type:Enzyme Subunit
Mol. Mass.:10738.15
Organism:Human immunodeficiency virus type 1
Description:L10I/N37S/R41K/M46I/I54V/I62V/L63P/A71V/V77I/V82A/L90M/I93L
Residue:99
Sequence:
PQITLWKRPIVTIKIGGQLKEALLDTGADDTVLEEMSLPGKWKPKIIGGIGGFVKVRQYD
QVPIEICGHKVIGTVLIGPTPANIIGRNLMTQLGCTLNF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM9121
HIV Protease Peptide Substrate
Name:HIV Protease Peptide Substrate
Synonyms:HIV Protease Substrate
Type:Peptide
Mol. Mass.:2715.95
Organism:n/a
Description:n/a
Residue:25
Sequence:
VSQN-(beta-naphthylalanine)-PIV