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TargetDimer of Gag-Pol polyprotein [489-587,Q496K,L499I,M535I,I543V,Q547E,L552P,I553V,V566I,V571F,I573V,L579M,I582L]
LigandBDBM9145
Substrate/CompetitorHIV Protease Peptide Substrate
Meas. Tech.Protease Inhibition Assay
pH5.5±n/a
Temperature303.15±n/a K
IC50 0.5±n/a nM
Citation Duffy, JLRano, TAKevin, NJChapman, KTSchleif, WAOlsen, DBStahlhut, MRutkowski, CAKuo, LCJin, LLin, JHEmini, EATata, JR HIV protease inhibitors with picomolar potency against PI-Resistant HIV-1 by extension of the P3 substituent. Bioorg Med Chem Lett13:2569-72 (2003) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Dimer of Gag-Pol polyprotein [489-587,Q496K,L499I,M535I,I543V,Q547E,L552P,I553V,V566I,V571F,I573V,L579M,I582L]
Name:Dimer of Gag-Pol polyprotein [489-587,Q496K,L499I,M535I,I543V,Q547E,L552P,I553V,V566I,V571F,I573V,L579M,I582L]
Synonyms:HIV-1 Protease Mutant (L10I/M46I/I54V/Q58E/L63P/I64V/V77I/V82F/I84V/L90M/I93L) | HIV-1 Protease Mutant K-60C
Type:Protein Complex
Mol. Mass.:n/a
Description:n/a
Components:This complex has 2 components.
Component 1
Name:Gag-Pol polyprotein [489-587,Q496K,L499I,M535I,I543V,Q547E,L552P,I553V,V566I,V571F,I573V,L579M,I582L]
Synonyms:HIV-1 Protease Mutant K-60C Chain A | HIV-1 Protease Mutant K-60C Chain B | POL_HV1N5 | gag-pol
Type:Enzyme Subunit
Mol. Mass.:10827.19
Organism:Human immunodeficiency virus type 1
Description:L10I,M46I,I54V,Q58E,L63P,I64V,V77I,V82F,I84V,L90M,I93L
Residue:99
Sequence:
PQITLWKRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFVKVREYD
QIPVEICGHKAIGTVLIGPTPFNVIGRNLMTQLGCTLNF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
Component 2
Name:Gag-Pol polyprotein [489-587,Q496K,L499I,M535I,I543V,Q547E,L552P,I553V,V566I,V571F,I573V,L579M,I582L]
Synonyms:HIV-1 Protease Mutant K-60C Chain A | HIV-1 Protease Mutant K-60C Chain B | POL_HV1N5 | gag-pol
Type:Enzyme Subunit
Mol. Mass.:10827.19
Organism:Human immunodeficiency virus type 1
Description:L10I,M46I,I54V,Q58E,L63P,I64V,V77I,V82F,I84V,L90M,I93L
Residue:99
Sequence:
PQITLWKRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFVKVREYD
QIPVEICGHKAIGTVLIGPTPFNVIGRNLMTQLGCTLNF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM9145
HIV Protease Peptide Substrate
Name:HIV Protease Peptide Substrate
Synonyms:HIV Protease Substrate
Type:Peptide
Mol. Mass.:2715.95
Organism:n/a
Description:n/a
Residue:25
Sequence:
VSQN-(beta-naphthylalanine)-PIV