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TargetDimer of Gag-Pol polyprotein [489-587,Q496K,L499I,M525I,N526D,M535I,R546K,L552P,A560V,G562S,I573V,L579M,I582L]
LigandBDBM9144
Substrate/CompetitorHIV Protease Peptide Substrate
Meas. Tech.Protease Inhibition Assay
pH5.5±n/a
Temperature303.15±n/a K
IC50 0.7±n/a nM
Citation Duffy, JLRano, TAKevin, NJChapman, KTSchleif, WAOlsen, DBStahlhut, MRutkowski, CAKuo, LCJin, LLin, JHEmini, EATata, JR HIV protease inhibitors with picomolar potency against PI-Resistant HIV-1 by extension of the P3 substituent. Bioorg Med Chem Lett13:2569-72 (2003) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Dimer of Gag-Pol polyprotein [489-587,Q496K,L499I,M525I,N526D,M535I,R546K,L552P,A560V,G562S,I573V,L579M,I582L]
Name:Dimer of Gag-Pol polyprotein [489-587,Q496K,L499I,M525I,N526D,M535I,R546K,L552P,A560V,G562S,I573V,L579M,I582L]
Synonyms:HIV-1 Protease Mutant (L10I/M36I/N37D/M46I/R57K/L63P/A71V/G73S/I84V/L90M/I93L) | HIV-1 Protease Mutant V-18C
Type:Protein Complex
Mol. Mass.:n/a
Description:n/a
Components:This complex has 2 components.
Component 1
Name:Gag-Pol polyprotein [489-587,Q496K,L499I,M525I,N526D,M535I,R546K,L552P,A560V,G562S,I573V,L579M,I582L]
Synonyms:HIV-1 Protease Mutant V-18C Chain A | HIV-1 Protease Mutant V-18C Chain B | POL_HV1N5 | gag-pol
Type:Enzyme Subunit
Mol. Mass.:10805.20
Organism:Human immunodeficiency virus type 1
Description:L10I/M36I/N37D/M46I/R57K/L63P/A71V/G73S/I84V/L90M/I93L
Residue:99
Sequence:
PQITLWKRPIVTIKIGGQLKEALLDTGADDTVLEEIDLPGRWKPKIIGGIGGFIKVKQYD
QIPIEICGHKVISTVLVGPTPVNVIGRNLMTQLGCTLNF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
Component 2
Name:Gag-Pol polyprotein [489-587,Q496K,L499I,M525I,N526D,M535I,R546K,L552P,A560V,G562S,I573V,L579M,I582L]
Synonyms:HIV-1 Protease Mutant V-18C Chain A | HIV-1 Protease Mutant V-18C Chain B | POL_HV1N5 | gag-pol
Type:Enzyme Subunit
Mol. Mass.:10805.20
Organism:Human immunodeficiency virus type 1
Description:L10I/M36I/N37D/M46I/R57K/L63P/A71V/G73S/I84V/L90M/I93L
Residue:99
Sequence:
PQITLWKRPIVTIKIGGQLKEALLDTGADDTVLEEIDLPGRWKPKIIGGIGGFIKVKQYD
QIPIEICGHKVISTVLVGPTPVNVIGRNLMTQLGCTLNF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM9144
HIV Protease Peptide Substrate
Name:HIV Protease Peptide Substrate
Synonyms:HIV Protease Substrate
Type:Peptide
Mol. Mass.:2715.95
Organism:n/a
Description:n/a
Residue:25
Sequence:
VSQN-(beta-naphthylalanine)-PIV