Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Histone-lysine N-methyltransferase EZH2 [Y641F] | ||
Ligand | BDBM172161 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | PRC2 Enzyme Assays | ||
IC50 | 2.74±n/a nM | ||
Citation | Kuntz, KW; Chesworth, R; Duncan, KW; Keilhack, H; Warholic, N; Klaus, C; Knutson, SK; Wigle, TJ; Seki, M; Shirotori, S; Kawano, S Aryl- or heteroaryl-substituted benzene compounds US Patent US10155002 Publication Date 12/18/2018 | ||
More Info.: | Get all data from this article, Assay Method | ||
Histone-lysine N-methyltransferase EZH2 [Y641F] | |||
Name: | Histone-lysine N-methyltransferase EZH2 [Y641F] | ||
Synonyms: | EZH2 | EZH2(Y641F) | EZH2_HUMAN | Histone-lysine N-methyltransferase EZH2 (Y641F) | KMT6 | ||
Type: | n/a | ||
Mol. Mass.: | 85351.84 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q15910[Y641F] | ||
Residue: | 746 | ||
Sequence: |
| ||
BDBM172161 | |||
n/a | |||
Name | BDBM172161 | ||
Synonyms: | US10155002, Compound 169 | US11052093, Compound 169 | US9090562, 169 | ||
Type | Small organic molecule | ||
Emp. Form. | C30H42N6O2 | ||
Mol. Mass. | 518.6935 | ||
SMILES | CCN([C@H]1CC[C@@H](CC1)N(C)C)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1nccn1C |r,wU:3.2,wD:6.9,(-2,4.65,;-3.33,3.88,;-3.33,2.34,;-4.67,1.57,;-4.67,.03,;-6,-.74,;-7.34,.03,;-7.34,1.57,;-6,2.34,;-8.67,-.74,;-10,.03,;-8.67,-2.28,;-2,1.57,;-2,.03,;-.67,-.74,;.67,.03,;.67,1.57,;2,2.34,;2,3.88,;3.33,1.57,;4.67,2.34,;6,1.57,;7.34,2.34,;7.34,3.88,;8.67,1.57,;8.67,.03,;10,-.74,;7.34,-.74,;6,.03,;4.67,-.74,;-.67,2.34,;-.67,3.88,;-.67,-2.28,;.58,-3.19,;.1,-4.65,;-1.44,-4.65,;-1.91,-3.19,;-3.25,-2.42,)| | ||
Structure |