Reaction Details | |||
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Target | Histone-lysine N-methyltransferase EZH2 [Y641F] | ||
Ligand | BDBM172164 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | PRC2 Enzyme Assays | ||
IC50 | 4.21±n/a nM | ||
Citation | Kuntz, KW; Chesworth, R; Duncan, KW; Keilhack, H; Warholic, N; Klaus, C; Knutson, SK; Wigle, TJ; Seki, M; Shirotori, S; Kawano, S Aryl- or heteroaryl-substituted benzene compounds US Patent US10155002 Publication Date 12/18/2018 | ||
More Info.: | Get all data from this article, Assay Method | ||
Histone-lysine N-methyltransferase EZH2 [Y641F] | |||
Name: | Histone-lysine N-methyltransferase EZH2 [Y641F] | ||
Synonyms: | EZH2 | EZH2(Y641F) | EZH2_HUMAN | Histone-lysine N-methyltransferase EZH2 (Y641F) | KMT6 | ||
Type: | n/a | ||
Mol. Mass.: | 85351.84 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q15910[Y641F] | ||
Residue: | 746 | ||
Sequence: |
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BDBM172164 | |||
n/a | |||
Name | BDBM172164 | ||
Synonyms: | US10155002, Compound 172 | US11052093, Compound 172 | US9090562, 172 | ||
Type | Small organic molecule | ||
Emp. Form. | C35H49N7O2 | ||
Mol. Mass. | 599.8093 | ||
SMILES | CCN([C@H]1CC[C@@H](CC1)N(C)C)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(nc1)N1CCNCC1 |r,wU:3.2,wD:6.9,(2.7,8,;1.93,6.67,;2.7,5.33,;4.24,5.33,;5.01,6.67,;6.55,6.67,;7.32,5.33,;6.55,4,;5.01,4,;8.86,5.33,;9.63,6.67,;9.63,4,;1.93,4,;.39,4,;-.38,2.67,;.39,1.33,;1.93,1.33,;2.7,,;4.24,,;1.93,-1.33,;2.7,-2.67,;1.93,-4,;2.7,-5.33,;4.24,-5.33,;1.93,-6.67,;.39,-6.67,;-.38,-8,;-.38,-5.33,;.39,-4,;-.38,-2.67,;2.7,2.67,;4.24,2.67,;-1.92,2.67,;-2.69,4,;-4.23,4,;-5,2.67,;-4.23,1.33,;-2.69,1.33,;-6.54,2.67,;-7.32,4,;-8.86,4,;-9.63,2.67,;-8.86,1.33,;-7.32,1.33,)| | ||
Structure |