| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] |
|---|
| Ligand | BDBM176749 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | MKNK1 Kinase High ATP Assay |
|---|
| pH | 7.5±n/a |
|---|
| IC50 | 20±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Klar, U; Wortmann, L; Graham, K; Puehler, F; Sülzle, D; Kettschau, G; Lienau, P Substituted thiazolopyrimidines US Patent US9675612 Publication Date 6/13/2017 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] |
|---|
| Name: | Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] |
|---|
| Synonyms: | Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] | Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D] | MAP kinase signal-integrating kinase 1 (MNK1) (T344D) | MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) | MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D) | MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)(T344D) | MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D] | MAP kinase-interacting serine/threonine-protein kinase 1 (T344D) | MKNK1 | MKNK1 (aa 1-424) T344D | MKNK1_HUMAN | MNK1 | MNK1a |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 47416.00 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9BUB5-2 with T344D |
|---|
| Residue: | 424 |
|---|
| Sequence: | MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAY
AKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRF
YLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKGIAHRDLKPENILCES
PEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKR
CDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWA
HISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPEKGLPDPQVLQRNSSTMDLTLF
AAEAIALNRQLSQHEENELAEEPEALADGLCSMKLSPPCKSRLARRRALAQAGRGEDRSP
PTAL
|
|
|
|---|
| BDBM176749 |
|---|
| n/a |
|---|
| Name | BDBM176749 |
|---|
| Synonyms: | US9675612, 4 2-Benzyl-N-(6-methoxy-1H-indazol-5-yl)[1,3]thiazolo[5,4-d]pyrimidin-7-amine |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H16N6OS |
|---|
| Mol. Mass. | 388.446 |
|---|
| SMILES | COc1cc2[nH]ncc2cc1Nc1ncnc2sc(Cc3ccccc3)nc12 |
|---|
| Structure | 
|
|---|
Search and Browse
