| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Acetylcholinesterase |
|---|
| Ligand | BDBM9411 |
|---|
| Substrate/Competitor | BDBM8959 |
|---|
| Meas. Tech. | Enzyme Inhibition Assay |
|---|
| IC50 | 0.6±n/a nM |
|---|
| Citation |  Sugimoto, H; Tsuchiya, Y; Sugumi, H; Higurashi, K; Karibe, N; Iimura, Y; Sasaki, A; Kawakami, Y; Nakamura, T; Araki, S Novel piperidine derivatives. Synthesis and anti-acetylcholinesterase activity of 1-benzyl-4-[2-(N-benzoylamino)ethyl]piperidine derivatives. J Med Chem33:1880-7 (1990) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Acetylcholinesterase |
|---|
| Name: | Acetylcholinesterase |
|---|
| Synonyms: | ACES_MOUSE | Acetylcholinesterase (AChE) | Acetylcholinesterase (mouse AChE) | Acetylcholinesterase precursor | Ache |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 68165.65 |
|---|
| Organism: | Mus musculus (mouse) |
|---|
| Description: | n/a |
|---|
| Residue: | 614 |
|---|
| Sequence: | MRPPWYPLHTPSLAFPLLFLLLSLLGGGARAEGREDPQLLVRVRGGQLRGIRLKAPGGPV
SAFLGIPFAEPPVGSRRFMPPEPKRPWSGVLDATTFQNVCYQYVDTLYPGFEGTEMWNPN
RELSEDCLYLNVWTPYPRPASPTPVLIWIYGGGFYSGAASLDVYDGRFLAQVEGAVLVSM
NYRVGTFGFLALPGSREAPGNVGLLDQRLALQWVQENIAAFGGDPMSVTLFGESAGAASV
GMHILSLPSRSLFHRAVLQSGTPNGPWATVSAGEARRRATLLARLVGCPPGGAGGNDTEL
IACLRTRPAQDLVDHEWHVLPQESIFRFSFVPVVDGDFLSDTPEALINTGDFQDLQVLVG
VVKDEGSYFLVYGVPGFSKDNESLISRAQFLAGVRIGVPQASDLAAEAVVLHYTDWLHPE
DPTHLRDAMSAVVGDHNVVCPVAQLAGRLAAQGARVYAYIFEHRASTLTWPLWMGVPHGY
EIEFIFGLPLDPSLNYTTEERIFAQRLMKYWTNFARTGDPNDPRDSKSPQWPPYTTAAQQ
YVSLNLKPLEVRRGLRAQTCAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKN
QFDHYSKQERCSDL
|
|
|
|---|
| BDBM9411 |
|---|
| BDBM8959 |
|---|
| Name | BDBM9411 |
|---|
| Synonyms: | CHEMBL54058 | N-[2-(1-benzylpiperidin-4-yl)ethyl]-N-phenyl-4-(phenylmethane)sulfonylbenzamide hydrochloride | Piperidine Derivative 23 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C34H36N2O3S |
|---|
| Mol. Mass. | 552.726 |
|---|
| SMILES | O=C(N(CCC1CCN(Cc2ccccc2)CC1)c1ccccc1)c1ccc(cc1)S(=O)(=O)Cc1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
