| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase SYK [342-635] |
|---|
| Ligand | BDBM311126 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | SYK Kinase Inhibition Test |
|---|
| IC50 | 0.900±n/a nM |
|---|
| Citation |  Hoffmann, M; Dahmann, G; Gnamm, C; Fandrick, DR; Scott, J; McCarthy, C Pyrazolyl-substituted heteroaryls and their use as medicaments US Patent US10155751 Publication Date 12/18/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein kinase SYK [342-635] |
|---|
| Name: | Tyrosine-protein kinase SYK [342-635] |
|---|
| Synonyms: | KSYK_HUMAN | SYK | SYK (aa 342-635) |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 34105.36 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P43405[342-635] |
|---|
| Residue: | 294 |
|---|
| Sequence: | PMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAV
KILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQ
QNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRA
DENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEV
TAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
|
|
|
|---|
| BDBM311126 |
|---|
| n/a |
|---|
| Name | BDBM311126 |
|---|
| Synonyms: | US10155751, Example 13 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H29N5O2 |
|---|
| Mol. Mass. | 395.498 |
|---|
| SMILES | C[C@@H](Oc1cc(cc2nn(C)c(C)c12)-c1cnn(c1)C(C)(C)C)[C@H]1CNC(=O)C1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
