Reaction Details |
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Target | AP2-associated protein kinase 1 |
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Ligand | BDBM311232 |
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Substrate/Competitor | n/a |
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Meas. Tech. | AAK1 Kinase Assay |
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IC50 | 0.460±n/a nM |
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Citation | Luo, G; Dzierba, CD; Macor, JE Biaryl kinase inhibitors US Patent US10155760 Publication Date 12/18/2018 |
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More Info.: | Get all data from this article, Assay Method |
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AP2-associated protein kinase 1 |
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Name: | AP2-associated protein kinase 1 |
Synonyms: | AAK1 | AAK1_HUMAN | Adaptor-associated kinase 1 | KIAA1048 |
Type: | PROTEIN |
Mol. Mass.: | 103884.23 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_774569 |
Residue: | 961 |
Sequence: | MKKFFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIGRVFGIGRQQVTVDEVLAEGGFAIV
FLVRTSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVW
EVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVE
NILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIIT
TKADIWALGCLLYKLCYFTLPFGESQVAICDGNFTIPDNSRYSQDMHCLIRYMLEPDPDK
RPDIYQVSYFSFKLLKKECPIPNVQNSPIPAKLPEPVKASEAAAKKTQPKARLTDPIPTT
ETSIAPRQRPKAGQTQPNPGILPIQPALTPRKRATVQPPPQAAGSSNQPGLLASVPQPKP
QAPPSQPLPQTQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQHQQQLFLKQQQQQQQPPP
AQQQPAGTFYQQQQAQTQQFQAVHPATQKPAIAQFPVVSQGGSQQQLMQNFYQQQQQQQQ
QQQQQQLATALHQQQLMTQQAALQQKPTMAAGQQPQPQPAAAPQPAPAQEPAIQAPVRQQ
PKVQTTPPPAVQGQKVGSLTPPSSPKTQRAGHRRILSDVTHSAVFGVPASKSTQLLQAAA
AEASLNKSKSATTTPSGSPRTSQQNVYNPSEGSTWNPFDDDNFSKLTAEELLNKDFAKLG
EGKHPEKLGGSAESLIPGFQSTQGDAFATTSFSAGTAEKRKGGQTVDSGLPLLSVSDPFI
PLQVPDAPEKLIEGLKSPDTSLLLPDLLPMTDPFGSTSDAVIEKADVAVESLIPGLEPPV
PQRLPSQTESVTSNRTDSLTGEDSLLDCSLLSNPTTDLLEEFAPTAISAPVHKAAEDSNL
ISGFDVPEGSDKVAEDEFDPIPVLITKNPQGGHSRNSSGSSESSLPNLARSLLLVDQLID
L
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BDBM311232 |
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n/a |
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Name | BDBM311232 |
Synonyms: | (S)-1-(4-(7-chloroquinolin-4-yl)-2-(trifluoromethyl)phenoxy)-2,4-dimethylpentan-2-amine | US10155760, Example 88 | US10351563, Example 88 | US10544120, Example 88 | US10723734, Example 88 | US10981910, Example 88 | US9902722, Example 88 |
Type | Small organic molecule |
Emp. Form. | C23H24ClF3N2O |
Mol. Mass. | 436.898 |
SMILES | CC(C)C[C@](C)(N)COc1ccc(cc1C(F)(F)F)-c1ccnc2cc(Cl)ccc12 |r| |
Structure |
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