| Reaction Details |
|---|
 | Report a problem with these data |
| Target | AP2-associated protein kinase 1 |
|---|
| Ligand | BDBM311382 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | AAK1 Kinase Assay |
|---|
| IC50 | 0.390±n/a nM |
|---|
| Citation |  Luo, G; Dzierba, CD; Macor, JE Biaryl kinase inhibitors US Patent US10155760 Publication Date 12/18/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| AP2-associated protein kinase 1 |
|---|
| Name: | AP2-associated protein kinase 1 |
|---|
| Synonyms: | AAK1 | AAK1_HUMAN | Adaptor-associated kinase 1 | KIAA1048 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 103884.23 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_774569 |
|---|
| Residue: | 961 |
|---|
| Sequence: | MKKFFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIGRVFGIGRQQVTVDEVLAEGGFAIV
FLVRTSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVW
EVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVE
NILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIIT
TKADIWALGCLLYKLCYFTLPFGESQVAICDGNFTIPDNSRYSQDMHCLIRYMLEPDPDK
RPDIYQVSYFSFKLLKKECPIPNVQNSPIPAKLPEPVKASEAAAKKTQPKARLTDPIPTT
ETSIAPRQRPKAGQTQPNPGILPIQPALTPRKRATVQPPPQAAGSSNQPGLLASVPQPKP
QAPPSQPLPQTQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQHQQQLFLKQQQQQQQPPP
AQQQPAGTFYQQQQAQTQQFQAVHPATQKPAIAQFPVVSQGGSQQQLMQNFYQQQQQQQQ
QQQQQQLATALHQQQLMTQQAALQQKPTMAAGQQPQPQPAAAPQPAPAQEPAIQAPVRQQ
PKVQTTPPPAVQGQKVGSLTPPSSPKTQRAGHRRILSDVTHSAVFGVPASKSTQLLQAAA
AEASLNKSKSATTTPSGSPRTSQQNVYNPSEGSTWNPFDDDNFSKLTAEELLNKDFAKLG
EGKHPEKLGGSAESLIPGFQSTQGDAFATTSFSAGTAEKRKGGQTVDSGLPLLSVSDPFI
PLQVPDAPEKLIEGLKSPDTSLLLPDLLPMTDPFGSTSDAVIEKADVAVESLIPGLEPPV
PQRLPSQTESVTSNRTDSLTGEDSLLDCSLLSNPTTDLLEEFAPTAISAPVHKAAEDSNL
ISGFDVPEGSDKVAEDEFDPIPVLITKNPQGGHSRNSSGSSESSLPNLARSLLLVDQLID
L
|
|
|
|---|
| BDBM311382 |
|---|
| n/a |
|---|
| Name | BDBM311382 |
|---|
| Synonyms: | (S)-1-((4-chloro-6-(6-chloroquinolin-4-yl)pyridin-3-yl)oxy)-2,4-dimethylpentan-2-amine | US10155760, Example 239 | US10351563, Example 239 | US10544120, Example 239 | US10723734, Example 239 | US10981910, Example 239 | US9902722, Example 239 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H23Cl2N3O |
|---|
| Mol. Mass. | 404.333 |
|---|
| SMILES | CC(C)C[C@](C)(N)COc1cnc(cc1Cl)-c1ccnc2ccc(Cl)cc12 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
