Reaction Details |
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Target | Aromatase |
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Ligand | BDBM9460 |
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Substrate/Competitor | BDBM8592 |
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Meas. Tech. | CYP19 Assay |
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pH | 7±n/a |
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Temperature | 310.15±n/a K |
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Ki | 1410±100 nM |
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IC50 | 2800±n/a nM |
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Km | 90±10 nM |
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Citation | Kim, YW; Hackett, JC; Brueggemeier, RW Synthesis and aromatase inhibitory activity of novel pyridine-containing isoflavones. J Med Chem47:4032-40 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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Aromatase |
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Name: | Aromatase |
Synonyms: | ARO1 | Aromatase | CP19A_HUMAN | CYAR | CYP19 | CYP19A1 | CYPXIX | Cytochrome P-450AROM | Cytochrome P450 19A1 | Cytochrome P450 2C19 | Cytochrome P450-C19 (CYP19) | Estrogen synthetase | FL cytokine receptor precursor | P-450AROM |
Type: | Enzyme |
Mol. Mass.: | 57888.92 |
Organism: | Homo sapiens (Human) |
Description: | P11511 |
Residue: | 503 |
Sequence: | MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLI
SHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKL
GLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTN
ESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWL
YKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCI
LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFI
YESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAK
NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLH
PDETKNMLEMIFTPRNSDRCLEH
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BDBM9460 |
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BDBM8592 |
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Name | BDBM9460 |
Synonyms: | 3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3-(4-aminophenyl)-3-ethylpiperidine-2,6-dione | Aminoglutethimide AG, 4 | CHEMBL488 | Cytadren | EN300-53368 | Elipten | aminoglutethimide (AG) |
Type | Small organic molecule |
Emp. Form. | C13H16N2O2 |
Mol. Mass. | 232.2783 |
SMILES | CCC1(CCC(=O)NC1=O)c1ccc(N)cc1 |
Structure |
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