| Reaction Details |
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 | Report a problem with these data |
| Target | Interleukin-1 receptor-associated kinase 4 |
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| Ligand | BDBM311516 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | IRAK4 Kinase Assay |
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| IC50 | 0.600±n/a nM |
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| Citation |  Lim, J; Altman, MD; Childers, ML; Gibeau, CR; Ho, GD; Tsui, H Carboxamide inhibitors of IRAK4 activity US Patent US10155765 Publication Date 12/18/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Interleukin-1 receptor-associated kinase 4 |
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| Name: | Interleukin-1 receptor-associated kinase 4 |
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| Synonyms: | IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64 |
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| Type: | Protein |
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| Mol. Mass.: | 51519.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NWZ3 |
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| Residue: | 460 |
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| Sequence: | MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALL
QTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITV
QQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNF
DERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKC
QHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGIN
FLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL
RGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMND
ADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
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| BDBM311516 |
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| n/a |
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| Name | BDBM311516 |
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| Synonyms: | 5-{[(3R,4R)-3- aminotetrahydro-2H- pyran-4-yl]amino}-N- (3-carbamoyl-1-methyl- 1H-pyrazol-4- yl)pyrazolo[1,5- a]pyrimidine-3- carboxamide trifluoroacetate | US10155765, Example 2 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H21N9O3 |
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| Mol. Mass. | 399.4071 |
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| SMILES | Cn1cc(NC(=O)c2cnn3ccc(N[C@@H]4CCOC[C@@H]4N)nc23)c(n1)C(N)=O |r| |
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| Structure | 
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