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TargetInterleukin-1 receptor-associated kinase 4
LigandBDBM311527
Substrate/Competitorn/a
Meas. Tech.IRAK4 Kinase Assay
IC50 2.00±n/a nM
Citation Lim, JAltman, MDChilders, MLGibeau, CRHo, GDTsui, H Carboxamide inhibitors of IRAK4 activity US Patent US10155765 Publication Date 12/18/2018
More Info.:Get all data from this article,  Assay Method
 
Interleukin-1 receptor-associated kinase 4
Name:Interleukin-1 receptor-associated kinase 4
Synonyms:IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:Protein
Mol. Mass.:51519.08
Organism:Homo sapiens (Human)
Description:Q9NWZ3
Residue:460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALL
QTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITV
QQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNF
DERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKC
QHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGIN
FLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL
RGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMND
ADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
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BDBM311527
n/a
NameBDBM311527
Synonyms:5-[(2- aminocycloheptyl)amino]- N-(3-carbamoyl-1- methyl-1H-pyrazol-4- yl)pyrazolo[1,5- a]pyrimidine-3- carboxamide | US10155765, Example 13
TypeSmall organic molecule
Emp. Form.C19H25N9O2
Mol. Mass.411.4609
SMILESCn1cc(NC(=O)c2cnn3ccc(NC4CCCCCC4N)nc23)c(n1)C(N)=O
Structure
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