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TargetInterleukin-1 receptor-associated kinase 4
LigandBDBM50095465
Substrate/Competitorn/a
Meas. Tech.IRAK4 Kinase Assay
IC50 2.00±n/a nM
Citation Lim JAltman MDChilders MLGibeau CRHo GDTsui H Carboxamide inhibitors of IRAK4 activity US Patent  US10155765 Publication Date 12/18/2018
More Info.:Get all data from this article,  Assay Method
 
Interleukin-1 receptor-associated kinase 4
Name:Interleukin-1 receptor-associated kinase 4
Synonyms:IRAK-4 | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:Protein
Mol. Mass.:51519.08
Organism:Homo sapiens (Human)
Description:Q9NWZ3
Residue:460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALL
QTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITV
QQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNF
DERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKC
QHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGIN
FLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL
RGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMND
ADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
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  Blast E-value cutoff:
BDBM50095465
n/a
NameBDBM50095465
Synonyms:CHEMBL3590438 | US10155765, Example 28
TypeSmall organic molecule
Emp. Form.C14H17N9O2
Mol. Mass.343.3439
SMILESCn1cc(NC(=O)c2cnn3ccc(NCCN)nc23)c(n1)C(N)=O
Structure
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