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TargetInterleukin-1 receptor-associated kinase 4
LigandBDBM311563
Substrate/Competitorn/a
Meas. Tech.IRAK4 Kinase Assay
IC50 0.700±n/a nM
Citation Lim JAltman MDChilders MLGibeau CRHo GDTsui H Carboxamide inhibitors of IRAK4 activity US Patent  US10155765 Publication Date 12/18/2018
More Info.:Get all data from this article,  Assay Method
 
Interleukin-1 receptor-associated kinase 4
Name:Interleukin-1 receptor-associated kinase 4
Synonyms:IRAK-4 | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:Protein
Mol. Mass.:51519.08
Organism:Homo sapiens (Human)
Description:Q9NWZ3
Residue:460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALL
QTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITV
QQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNF
DERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKC
QHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGIN
FLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL
RGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMND
ADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
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  Blast E-value cutoff:
BDBM311563
n/a
NameBDBM311563
Synonyms:2-{[(1R,2S)-2- aminocyclohexyl]amino}- N-(3-carbamoyl-1- methyl-1H-pyrazol-4- yl)pyrrolo[2,1- f][1,2,41triazine-7- carboxamide trifluoroacetate | US10155765, Example 61
TypeSmall organic molecule
Emp. Form.C18H23N9O2
Mol. Mass.397.4343
SMILESCn1cc(NC(=O)c2ccc3cnc(N[C@@H]4CCCC[C@@H]4N)nn23)c(n1)C(N)=O |r|
Structure
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