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TargetVoltage-dependent calcium channel gamma-2 subunit
LigandBDBM311766
Substrate/Competitorn/a
Meas. Tech.Calcium Flux Assay
IC50 0.025±n/a nM
Citation Ameriks MKLaforteza BNLebold TPRavula SSavall BMShireman BT Fused azaheterocyclic compounds and their use as AMPA receptor modulators US Patent  US10155769 Publication Date 12/18/2018
More Info.:Get all data from this article,  Assay Method
 
Voltage-dependent calcium channel gamma-2 subunit
Name:Voltage-dependent calcium channel gamma-2 subunit
Synonyms:CACNG2 | Neuronal voltage-gated calcium channel gamma-2 subunit | TARP gamma-2 | Transmembrane AMPAR regulatory protein gamma-2
Type:Enzyme Catalytic Domain
Mol. Mass.:35977.54
Organism:Homo sapiens (Human)
Description:n/a
Residue:323
Sequence:
MGLFDRGVQMLLTTVGAFAAFSLMTIAVGTDYWLYSRGVCKTKSVSENETSKKNEEVMTH
SGLWRTCCLEGNFKGLCKQIDHFPEDADYEADTAEYFLRAVRASSIFPILSVILLFMGGL
CIAASEFYKTRHNIILSAGIFFVSAGLSNIIGIIVYISANAGDPSKSDSKKNSYSYGWSF
YFGALSFIIAEMVGVLAVHMFIDRHKQLRATARATDYLQASAITRIPSYRYRYQRRSRSS
SRSTEPSHSRDASPVGIKGFNTLPSTEISMYTLSRDPLKAATTPTATYNSDRDNSFLQVH
NCIQKENKDSLHSNTANRRTTPV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM311766
n/a
NameBDBM311766
Synonyms:2-Cyclobutyl-7-(4-fluorophenyl)-8-(7-methyl-1H-indazol-5-yl)-[1,2,4]triazolo[1,5-a]pyridine | US10155769, Example 4
TypeSmall organic molecule
Emp. Form.C24H20FN5
Mol. Mass.397.4475
SMILESCc1cc(cc2cn[nH]c12)-c1c(ccn2nc(nc12)C1CCC1)-c1ccc(F)cc1
Structure
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