| Reaction Details |
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 | Report a problem with these data |
| Target | Tryptophan 2,3-dioxygenase |
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| Ligand | BDBM50126144 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | TDO Coupled Biochemical Assays |
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| IC50 | 501±n/a nM |
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| Citation |  Hunter, B; McElroy, S; Wise, A Screening method US Patent US10155972 Publication Date 12/18/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Tryptophan 2,3-dioxygenase |
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| Name: | Tryptophan 2,3-dioxygenase |
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| Synonyms: | T23O_HUMAN | TDO | TDO2 | TO | TRPO | Tryptamin 2,3-dioxygenase | Tryptophan oxygenase | Tryptophan pyrrolase | Tryptophanase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 47874.48 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_825691 |
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| Residue: | 406 |
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| Sequence: | MSGCPFLGNNFGYTFKKLPVEGSEEDKSQTGVNRASKGGLIYGNYLHLEKVLNAQELQSE
TKGNKIHDEHLFIITHQAYELWFKQILWELDSVREIFQNGHVRDERNMLKVVSRMHRVSV
ILKLLVQQFSILETMTALDFNDFREYLSPASGFQSLQFRLLENKIGVLQNMRVPYNRRHY
RDNFKGEENELLLKSEQEKTLLELVEAWLERTPGLEPHGFNFWGKLEKNITRGLEEEFIR
IQAKEESEEKEEQVAEFQKQKEVLLSLFDEKRHEHLLSKGERRLSYRALQGALMIYFYRE
EPRFQVPFQLLTSLMDIDSLMTKWRYNHVCMVHRMLGSKAGTGGSSGYHYLRSTVSDRYK
VFVDLFNLSTYLIPRHWIPKMNPTIHKFLYTAEYCDSSYFSSDESD
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| BDBM50126144 |
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| n/a |
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| Name | BDBM50126144 |
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| Synonyms: | CHEMBL3629569 | US10155972, Compound NewLink 1 | US10233190, Example 1304 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H22N2O |
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| Mol. Mass. | 282.3801 |
|---|
| SMILES | OC(CC1c2ccccc2-c2cncn12)C1CCCCC1 |
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| Structure | 
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