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TargetDimer of Gag-Pol polyprotein [489-587]
LigandBDBM9645
Substrate/CompetitorBiotinylated HIV-1 Protease Peptide Substrate
Meas. Tech.Protease Inhibition Assay
IC50 0.77±n/a nM
Citation Jungheim, LN; Shepherd, TA; Baxter, AJ; Burgess, J; Hatch, SD; Lubbehusen, P; Wiskerchen, M; Muesing, MA Potent human immunodeficiency virus type 1 protease inhibitors that utilize noncoded D-amino acids as P2/P3 ligands. J Med Chem39:96-108 (1996) [PubMed]  Article
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Dimer of Gag-Pol polyprotein [489-587]
Name:Dimer of Gag-Pol polyprotein [489-587]
Synonyms:HIV-1 Protease
Type:Protein Complex
Mol. Mass.:n/a
Description:n/a
Components:This complex has 2 components.
Component 1
Name:Gag-Pol polyprotein [489-587]
Synonyms:HIV protease | HIV-1 Protease (NY5-type sequence) | HIV-1 Protease chain A | HIV-1 Protease chain B | POL_HV1N5 | gag-pol
Type:Enzyme Subunit
Mol. Mass.:10822.21
Organism:Human immunodeficiency virus type 1
Description:P12497[489-587]
Residue:99
Sequence:
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
Component 2
Name:Gag-Pol polyprotein [489-587]
Synonyms:HIV protease | HIV-1 Protease (NY5-type sequence) | HIV-1 Protease chain A | HIV-1 Protease chain B | POL_HV1N5 | gag-pol
Type:Enzyme Subunit
Mol. Mass.:10822.21
Organism:Human immunodeficiency virus type 1
Description:P12497[489-587]
Residue:99
Sequence:
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM9645
Biotinylated HIV-1 Protease Peptide Substrate
Name:Biotinylated HIV-1 Protease Peptide Substrate
Synonyms:n/a
Type:Peptide
Mol. Mass.:2106.93
Organism:n/a
Description:n/a
Residue:19
Sequence:
Biotin-GSQNYPIVGK(FITC)-OH